Oct 2, 2003

Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial

Journal of the National Cancer Institute
Anna J Duffield-LillicoNutritional Prevention of Cancer Study Group

Abstract

The Nutritional Prevention of Cancer Trial was a double-blind, randomized, placebo-controlled clinical trial designed to test whether selenium as selenized yeast (200 microg daily) could prevent nonmelanoma skin cancer among 1312 patients from the Eastern United States who had previously had this disease. Results from September 15, 1983, through December 31, 1993, showed no association between treatment and the incidence of basal and squamous cell carcinomas of the skin. This report summarizes the entire blinded treatment period, which ended on January 31, 1996. The association between treatment and time to first nonmelanoma skin cancer diagnosis and between treatment and time to multiple skin tumors overall and within subgroups, defined by baseline characteristics, was evaluated. Although results through the entire blinded period continued to show that selenium supplementation was not statistically significantly associated with the risk of basal cell carcinoma (hazard ratio [HR] = 1.09, 95% confidence interval [CI] = 0.94 to 1.26), selenium supplementation was associated with statistically significantly elevated risk of squamous cell carcinoma (HR = 1.25, 95% CI = 1.03 to 1.51) and of total nonmelanoma skin cancer (HR = 1.17, ...Continue Reading

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Mentioned in this Paper

Malignant Neoplasm of Skin
Antineoplastic Agents
Selenium
Clinical Trials, Randomized
Yeasts
Pigmented Basal Cell Carcinoma
Odds Ratio
Squamous Cell Carcinoma
Skin Neoplasms
Clinical Trials

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