PMID: 2484402Apr 1, 1989Paper

Selenium supplementation of symptomatic human immunodeficiency virus infected patients

Biological Trace Element Research
L OlmstedJ Dowd

Abstract

The mean whole blood selenium levels in male San Diego, CA patients with acquired immune deficiency syndrome (AiDS) are 0.123 +/- 0.030 micrograms/mL (n = 24), and 0.126 +/- 0.038 micrograms/mL (n = 26) in patients with AIDS-related complex (ARC), compared to 0.195 +/- 0.020 micrograms/mL (n = 28) in San Diego healthy controls (males). To establish whether intestinal absorption of dietary selenium is impaired in AIDS or ARC, a supplementation trial was conducted in which 19 symptomatic HIV-antibody positive male patients with AIDS or ARC were taking 400 micrograms of selenium/d in form of selenium yeast for up to 70 d. The mean whole blood Se levels increased to 0.28 +/- 0.08 micrograms/mL after 70 d of supplementation, the selenium supplements were well tolerated. A rationale for adjuvant selenium supplementation of symptomatic and asymptomatic HIV carriers is proposed.

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Citations

Jan 1, 1993·Archives of Toxicology·M ToborekE Kopieczna-Grzebieniak
Jan 1, 1997·Biological Trace Element Research·E W TaylorC S Ramanathan
Jun 1, 1995·Biological Trace Element Research·E SunJ Wang
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Apr 3, 2020·Biological Trace Element Research·Karen Cilliers, Christo J F Muller
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