Selenium unmasks protective iron armor: A possible defense against cutaneous inflammation and cancer

Biochimica Et Biophysica Acta. General Subjects
Jack L ArbiserShikha Rao

Abstract

A link between selenium deficiency and inflammatory skin diseases have been noted by many, but this link is still not well understood. We have previously studied the efficacy of ceramide analogs, based on the fire ant venom Solenopsin A, against our psoriasis animal model. Treatment of animals with solenopsin analogs resulted in significantly improved skin as well as in a coordinate downregulation of selenoproteins, namely Glutathione Peroxidase 4 (GPX4). We thus hypothesize that ferroptosis may be a physiologic process that may protect the skin from both inflammatory and neoplastic processes. We analyze and compare gene expression profiles in the GEO database from clinical skin samples taken from healthy patients and psoriasis patients (both involved and noninvolved skin lesions). We validated the gene expression results against a second, independent, cohort from the GEO database. Significant reduction in gene expression of GPX4, elevated expression of Nrf2 downstream targets, and expression profiles mirroring erastin-inhibition of Cystine/Glutamate Antiporter-System XC activity in psoriatic skin lesions, compared to both noninvolved skin and healthy patient samples, suggest an innately inducible mechanism of ferroptosis. We p...Continue Reading

Citations

Feb 6, 2020·Cell Death & Disease·Jie LiGang Wang
Sep 7, 2020·Pharmacology & Therapeutics·Anna FishbeinDipak Panigrahy
Apr 3, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yitian SunGuoxiong Li
Jan 24, 2021·Journal of the American Academy of Dermatology·Allen S W OakCraig A Elmets

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