Selenium-vitamin E combination modulates endometrial lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat

Biological Trace Element Research
Mehmet Güney

Abstract

Diabetes mellitus is associated with diabetic impairment of uterine function, ultimately leading to reduced fertility. Its etiology may involve oxidative damage by reactive oxygen substances, and protection against this damage can be offered by antioxidant supplementation. In the present study, the effects of a vitamin E-plus-selenium (VESe) combination on lipid peroxidation (MDA) and the scavenging enzyme activity in the uterine endometrium of streptozotocin (STZ)-induced diabetic rats were investigated. Twenty-four female rats were equally divided into three groups as follows: group I (control); group II (diabetic); group III (diabetic + VESe), STZ + vitamin E (60 mg/kg over 1 day) + selenium-treated (Na2SeO3, 1 mg/kg over 1 day). After 4 weeks of receiving the VESe treatment, endometrium samples were taken from the uterus. Although the VESe treatment decreased the MDA and blood glucose levels in the STZ group, the observed values remained significantly higher than in the controls. Catalase, superoxide dismutase, and glutathione peroxidase activities and body weight gain were significantly (p < 0.01) lower in STZ groups as compared to control group, whereas their activities were (p < 0.01) increased by VESe treatment. However...Continue Reading

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Citations

Sep 13, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Zhao YaoXiaoping Zhang
Feb 15, 2018·Oxidative Medicine and Cellular Longevity·Ning WangYibin Feng
Jun 19, 2020·Journal of Diabetes and Metabolic Disorders·Leonardo Parreira Silva NascimentoOdair Aguiar Junior

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