Selenium Yeast Alleviates Ochratoxin A-Induced Apoptosis and Oxidative Stress via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in the Kidneys of Chickens

Oxidative Medicine and Cellular Longevity
Kang LiJianbin He

Abstract

The purpose of this study was to investigate the protective effect and mechanism of yeast selenium (Se-Y) on ochratoxin- (OTA-) induced nephrotoxicity of chickens. A total of 80 one-day-old healthy chickens were randomly divided into 4 equal groups: control, OTA (50 μg/kg OTA), Se-Y (0.4 mg/kg Se-Y), and OTA+Se-Y (50 μg/kg OTA+0.4 mg/kg Se-Y). In the OTA chickens, differences in body weight, kidney coefficient, biochemical histological analysis, antioxidant capability, and the expression levels of the PI3K/AKT and Nrf2/Keap1 signaling pathway-related genes were observed. The levels of total superoxide dismutase (T-SOD), antioxidant capacity (T-AOC), catalase (CAT), and glutathione (T-GSH) significantly decreased, but the malondialdehyde (MDA) level of the kidneys significantly increased in the OTA treatment group. More importantly, treatment with Se-Y improved the antioxidant enzyme activities within the kidneys of chickens exposed to OTA. In addition, administration of OTA resulted in apoptosis and was associated with decreased expression of AKT, PI3K, and Bcl-2, which in turn enhanced expression of Caspase3, Bax, and P53. However, Se-Y improved the antioxidant defense system through activation of the Nrf2/Keap1 signaling path...Continue Reading

References

Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·L E Otterbein, A M Choi
Feb 14, 2002·The Journal of Biological Chemistry·Fuminori TsurutaYukiko Gotoh
Dec 10, 2003·Oncogene·Thomas F FrankeChizuru Sugimoto
Oct 28, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·M Marin-KuanB Schilter
Jul 21, 2006·Avian Pathology : Journal of the W.V.P.A·M A ElaroussiM H Hatab
Nov 18, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christophe CavinBenoît Schilter
Dec 30, 2006·Molecular Nutrition & Food Research·Annie Pfohl-Leszkowicz, Richard A Manderville
Jun 13, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C Boesch-SaadatmandiG Rimbach
May 6, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christophe CavinBenoît Schilter
Oct 25, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yoon-Jin LeeSang-Han Lee
Apr 1, 2010·Toxins·Lalini Reddy, Kanti Bhoola
Jul 1, 2010·Toxins·Gianni BattaconeGiuseppe Pulina
Oct 25, 2013·Toxins·Valeria SorrentiFabio Galvano
Dec 20, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Edyta ReszkaWojciech Wasowicz
Jan 16, 2015·Redox Biology·Helmut Sies
Feb 17, 2015·Journal of Basic Microbiology·Walter P PflieglerIstván Pócsi
Sep 24, 2015·International Journal of Medical Sciences·Chih-Hung GuoPei-Chung Chen
Oct 28, 2015·Toxins·Alexandra H Heussner, Lewis E H Bingle
Dec 3, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·João G CostaNuno G Oliveira
Jan 26, 2017·Frontiers in Microbiology·Vania C LiuzziGiuseppina Mulè
Jul 16, 2017·Toxicology·Agnieszka LobodaJozef Dulak
Jul 18, 2017·Toxicon : Official Journal of the International Society on Toxinology·Shanel RaghubeerAnil A Chuturgoon
Aug 2, 2017·Regulatory Toxicology and Pharmacology : RTP·Daniela E MarinIonelia Taranu
Aug 19, 2017·Toxins·Laura EscriváHouda Berrada
Oct 31, 2017·Chemico-biological Interactions·Yajiao ZhouKehe Huang
Jan 9, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yanfei TaoZonghui Yuan
Jul 13, 2018·Frontiers in Microbiology·Wenying ChenXiao L Shen
Sep 30, 2018·Biological Trace Element Research·Zhihua RenJunliang Deng
Nov 6, 2018·Biological Trace Element Research·Erhui JinShenghe Li
Nov 20, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ariane VettorazziAdela López de Cerain
Dec 28, 2018·Toxins·Bhagavathi Sundaram SivamaruthiChaiyavat Chaiyasut

❮ Previous
Next ❯

Citations

Feb 9, 2021·Archives of Toxicology·Marta Justyna KoziełAgnieszka Wanda Piastowska-Ciesielska

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
light microscopy
Assay
MDA
PCR
Protein Extraction
Protein Assay

Software Mentioned

SPSS

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.