Selenogenome and AMPK signal insight into the protective effect of dietary selenium on chronic heat stress-induced hepatic metabolic disorder in growing pigs.

Journal of Animal Science and Biotechnology
Yan LiuHua Zhao

Abstract

Chronic heat stress (CHS) disrupts hepatic metabolic homeostasis and jeopardizes product quality of pigs. Selenium (Se) may regulate the metabolic state through affect selenoprotein. Thus, we investigate the protective effect of dietary hydroxy-4-methylselenobutanoic acid (HMSeBA) on CHS induced hepatic metabolic disorder in growing pigs, and the corresponding response of selenoprotein. Forty crossbreed growing pigs were randomly assigned to five groups: control group raised in the thermoneutral environment (22 ± 2 °C) with basal diet; four CHS groups raised in hyperthermal condition (33 ± 2 °C) with basal diet and supplied with 0.0, 0.2, 0.4, and 0.6 mg Se/kg HMSeBA, respectively. The trial lasted 28 d. The serum biochemical, hepatic metabolism related enzyme, protein and gene expression and 25 selenoproteins in liver tissue were determined by real-time PCR, ELISA and western blot. CHS significantly increased the rectal temperature, respiration rate, serum aspartate aminotransferase (AST) and low-density lipoprotein cholesterol (LDL-C) of pigs, up-regulated hepatic heat shock protein 70 (HSP70) and induced lower liver weight, glycogen content, hepatic glucokinase and glutathione peroxidase (GSH-Px). The CHS-induced liver metab...Continue Reading

References

Jan 1, 1987·Annual Review of Nutrition·E R Miller, D E Ullrey
Aug 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T FerreA Valera
Oct 6, 1998·Annual Review of Biochemistry·D G HardieM Carlson
Jun 14, 2002·FEBS Letters·Dae won JeongIck Young Kim
Jun 21, 2002·The New England Journal of Medicine·Abderrezak Bouchama, James P Knochel
Sep 4, 2003·Genome Biology·Dov GreenbaumMark Gerstein
Oct 16, 2004·Molecular and Cellular Biology·Marcus ConradMarkus Brielmeier
Aug 2, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Daniele Del RioNicoletta Pellegrini
Dec 2, 2005·The Journal of Biological Chemistry·Andrew D FergusonJohann Deisenhofer
Nov 25, 2006·Experimental Cell Research·Marzanna DeniziakAlain Lescure
Jan 8, 2008·World Journal of Gastroenterology : WJG·J M GarcinF Cointet
Oct 24, 2009·FEBS Letters·Tobias MaierLuis Serrano
Jul 22, 2011·Nature·F Ulrich HartlManajit Hayer-Hartl
Feb 22, 2012·Free Radical Biology & Medicine·Min-Shu ZengXin Gen Lei
Feb 24, 2012·PloS One·Małgorzata DudkiewiczKrzysztof Pawłowski
Nov 22, 2012·Acta Physiologica·T YoshiharaS Katamoto
Jan 29, 2013·Molecular and Cellular Endocrinology·Gregory R Steinberg
Jan 31, 2013·Toxicology and Applied Pharmacology·Makoto YamazakiLining Guo
Mar 7, 2013·Journal of Animal Science·S C PearceL H Baumgard
Jul 23, 2013·Free Radical Biology & Medicine·Jun ZhouXin Gen Lei
Feb 27, 2015·Physiological Reports·M Victoria Sanz FernandezLance H Baumgard
May 15, 2015·The Journal of Nutrition·Hua ZhaoXin Gen Lei
Nov 20, 2016·Plant Biotechnology Journal·Pierre JacobAbdelhafid Bendahmane
Jan 6, 2017·Brain : a Journal of Neurology·Mustafa Y AhmedAndrew H Crosby
Nov 21, 2017·Journal of Dairy Science·R J CollierY Xiao
Nov 22, 2017·The Science of the Total Environment·Pei ZhangChangjiang Liu
Feb 1, 2018·Journal of Animal Science·J T SeibertL H Baumgard

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