Selenoprotein deficiency enhances radiation-induced micronuclei formation

Molecular Nutrition & Food Research
Manjeshwar S BaligaAlan M Diamond

Abstract

The availability of selenium and the levels of specific selenoproteins might affect cancer risk by influencing the ability of DNA damaging agents to cause genomic instability and mutations. Transgenic mice that express reduced levels of selenoproteins and previously shown to be more susceptible to pathology associated with cancer development were used to study this possibility. These mice were exposed to X-rays and DNA damage assessed in the erythrocytes, where micronuclei formation was higher compared to the same cells obtained from irradiated wild-type controls. To determine whether the selenoprotein glutathione peroxidase-1 (GPx-1) might be involved in this protection, its levels were reduced by siRNA targeting in LNCaP human prostate cells. UV-induced micronuclei frequency was higher in these cells compared to control-transfected cells. These results indicate a role for selenoproteins in protecting DNA from damage and support human data implicating GPx-1 as a possible target of the chemoprotective effect of selenium.

References

Feb 1, 1985·Mutation Research·M Fenech, A A Morley
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·M R BöslM M Taketo
May 9, 2002·Molecular and Cellular Biology·Dolph L Hatfield, Vadim N Gladyshev
May 23, 2002·Photochemistry and Photobiology·Jean-Roch MeunierLaurent Marrot
Sep 6, 2002·Oncogene·M Christine Hollander, Albert J Fornace
Jan 14, 2003·Annual Review of Nutrition·Donna M Driscoll, Paul R Copeland
Feb 18, 2003·Molecular and Cellular Biology·Easwari KumaraswamyDolph L Hatfield
May 6, 2003·The Journal of Nutrition·John R ArthurGeoffrey J Beckett
May 31, 2003·Science·Gregory V KryukovVadim N Gladyshev
Jun 19, 2004·Free Radical Biology & Medicine·Mohamed A NasrAlan M Diamond
Oct 30, 2004·The Journal of Nutrition·Veda Diwadkar-Navsariwala, Alan M Diamond
May 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Veda Diwadkar-NavsariwalaAlan M Diamond
Jul 13, 2007·Biological Trace Element Research·Manjeshwar S BaligaAlan M Diamond

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Citations

Dec 11, 2008·Biological Trace Element Research·Leila FarzinHadi Shams
Nov 20, 2010·Antioxidants & Redox Signaling·Edith LubosDiane E Handy
Sep 29, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bradley A CarlsonDolph L Hatfield
Feb 4, 2014·Trends in Biochemical Sciences·Dolph L HatfieldVadim N Gladyshev
Mar 13, 2012·Annual Review of Nutrition·Cindy D DavisJohn A Milner
Dec 26, 2009·Radiation and Environmental Biophysics·Jaroslaw DziegielewskiJanet E Baulch
Apr 30, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Esther Humann-ZiehankMartin Ganter
Feb 6, 2010·International Journal of Radiation Oncology, Biology, Physics·Ralph MueckeUNKNOWN German Working Group Trace Elements and Electrolytes in Oncology-AKTE
Mar 18, 2009·Biochimica Et Biophysica Acta·Pin Zhuo, Alan M Diamond
Jan 6, 2011·Molecular Nutrition & Food Research·Anita Jerome-MoraisMargaret E Wright
Jan 8, 2014·Molecular Nutrition & Food Research·Emmanuel AnsongAlan M Diamond
Dec 3, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiaokang ZhuYang Song
Dec 4, 2012·Biochimica Et Biophysica Acta·Regina Brigelius-Flohé, Matilde Maiorino
Mar 24, 2012·Biochimica Et Biophysica Acta·Marina V KasaikinaVadim N Gladyshev
Jul 15, 2015·Radiation Oncology Journal·Seyed Jalal Hosseinimehr
Dec 19, 2015·Physiological Reviews·Xin Gen LeiElias S J Arnér
Mar 16, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joyce C McCann, Bruce N Ames
Jul 14, 2019·Biological Trace Element Research·Alan M Diamond
Oct 20, 2018·Current Cancer Drug Targets·María Jesús Ramírez-ExpósitoJosé Manuel Martínez-Martos
May 22, 2018·Free Radical Biology & Medicine·Li ZhangWen-Hsing Cheng

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