Abstract
Selenium is a trace mineral that, as a constituent of certain selenoproteins, acts as an antioxidant. Results of studies addressing a cancer protective effect of selenium have been controversial. The present study measured selenoprotein-P, extracellular glutathione peroxidase, and plasma selenium in patients with colon cancer and adenomatous colon polyps to determine whether patients who develop colorectal adenomas or cancer are selenium deficient. Patients who presented to an endoscopy center for colonoscopy or who were referred to our institution with a newly diagnosed colorectal cancer were offered enrollment in the trial. Each patient underwent phlebotomy, usually immediately after colonoscopy. In all, 103 patients were enrolled in the study. Of these, 33 patients were found to have colorectal cancer, 35 adenomatous colon polyps, and 17 normal examinations. A total of 18 patients had other diagnoses and were not included in the study group. The mean age for the colorectal cancer group was 69 yr, for the adenomatous colon polyp group 62 yr, and for the normal group was 56 yr. The adenomatous colon polyp and normal groups were predominantly female. Based on one way analysis of variance tests, there was no significant differen...Continue Reading
References
Jun 1, 1991·Biological Trace Element Research·S Y YuC Hou
Feb 1, 1990·The Science of the Total Environment·Y X WangL B Yan
Nov 1, 1989·American Journal of Epidemiology·D W WestA W Sorensen
Sep 1, 1989·The Journal of Nutrition·Y M XiaR F Burk
Sep 1, 1988·American Journal of Epidemiology·S GrahamD West
Aug 15, 1986·International Journal of Cancer. Journal International Du Cancer·G Macquart-MoulinN Day
Dec 15, 1988·Cancer·K JaskiewiczE W Heine Tech
Dec 15, 1980·International Journal of Cancer. Journal International Du Cancer·M JainA B Miller
Jan 1, 1996·The Journal of Nutrition·K E HillR F Burk
Dec 25, 1996·JAMA : the Journal of the American Medical Association·L C ClarkJ R Taylor
Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R F BurkM E Boeglin
Jan 23, 1999·The New England Journal of Medicine·C S FuchsW C Willett
Apr 20, 2000·The New England Journal of Medicine·A SchatzkinJ Cahill
Apr 20, 2000·The New England Journal of Medicine·D S AlbertsR E Sampliner
Aug 31, 2000·Nutrition and Cancer·H MörkJ Köhrle
Sep 25, 2001·BioFactors·R F BurkA K Motley
Citations
Mar 30, 2010·The British Journal of Nutrition·Ying HuGraeme P Young
Nov 18, 2004·Journal of the National Cancer Institute·Elizabeth T JacobsMaría Elena Martínez
Nov 18, 2004·Journal of the National Cancer Institute·Anna J Duffield-LillicoScott M Lippman
Jun 21, 2012·PloS One·Yumie TakataUlrike Peters
Jul 18, 2006·Alimentary Pharmacology & Therapeutics·G BjelakovicC Gluud
Dec 16, 2016·ChemMedChem·Silong ZhangHai-Bing Zhou
Feb 11, 2005·Analytical and Bioanalytical Chemistry·Stefan StürupUlrike Peters
Aug 19, 2007·Journal of Clinical Gastroenterology·Elizabeth T JacobsMaría Elena Martínez
Jun 17, 2008·European Journal of Nutrition·Jolanta GromadzińskaBjörn Akesson
Oct 12, 2005·International Journal of Cancer. Journal International Du Cancer·Mary E ReidJames R Marshall
Dec 31, 2005·Annals of the New York Academy of Sciences·Mark A NelsonPeter Lance
Nov 5, 2013·Metallomics : Integrated Biometal Science·Marco RomanCarlo Barbante
Sep 23, 2003·Anti-cancer Drugs·M S StrattonF R Ahmann
Sep 23, 2003·Anti-cancer Drugs·M S StrattonF R Ahmann
Dec 23, 2003·Alimentary Pharmacology & Therapeutics·E D J CourtneyR J Leicester
Mar 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alexandra Connelly-FrostRobert S Sandler