PMID: 7931697Oct 1, 1994Paper

Selenoprotein P. A selenium-rich extracellular glycoprotein

The Journal of Nutrition
Raymond F Burk, K E Hill


Selenoprotein P is a glycoprotein that has been purified from rat and human plasma. In selenium-replete rats it contains 65% of the plasma selenium and its concentration is 25-30 mg protein/L. In selenium-deficient rats its concentration is < 3 mg protein/L. The plasma half life of 75Se in selenoprotein P is 3 to 4 h, indicating a rapid turnover. Purified rat selenoprotein P contains 7.5 +/- 1 selenium atoms per molecule as selenocysteine. The sequence of the cloned cDNA predicts 10 selenocysteine residues, which suggests that the protein in plasma is a modification of the predicted one. Deduced amino acid sequence identity between rats and humans is 72%. The 3' untranslated region of selenoprotein P cDNA contains two predicted stem loops of the type essential for selenocysteine incorporation. Northern analysis indicates that selenoprotein P is expressed by many tissues. Hepatic selenoprotein P mRNA level, but not its transcription, decreases during selenium deficiency. The decrease is less than the decrease of glutathione peroxidase mRNA, however. Selenoprotein P is postulated to serve as an extracellular oxidant defense because its presence correlates with selenium protection of selenium-deficient rats against diquat-induced ...Continue Reading


May 1, 1995·Nature Medicine·C Gauntt, S Tracy
Sep 1, 1996·Biological Trace Element Research·L A Daniels
May 20, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R F Burk, K E Hill
May 18, 1999·Biological Trace Element Research·Q LiuJ Clausen
Dec 28, 1999·BioFactors·M MaiorinoF Ursini
Nov 15, 2000·Biological Chemistry·J KöhrlL Flohé
Apr 24, 2004·Free Radical Research·Henrik TraulsenHelmut Sies
Aug 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R Moreno-ReyesA Schoutens
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Sep 24, 2004·Physiological Reviews·Roland Stocker, John F Keaney
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Oct 8, 1999·Journal of the American College of Nutrition·M JanghorbaniL Daniels
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Apr 9, 2005·The American Journal of Clinical Nutrition·Yiming XiaRaymond F Burk
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