Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Luca GrumolatoYoussef Anouar

Abstract

Selenoproteins contain the essential trace element selenium, the deficiency of which is associated with cancer or accelerated aging. Although selenoproteins are thought to be instrumental for the effects of selenium, the biological function of many of these proteins remains unknown. Here, we studied the role of selenoprotein T (SelT), a selenocysteine (Sec) -containing protein with no known function, which we have identified as a novel target gene of the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) during PC12 cell differentiation. SelT was found to be ubiquitously expressed throughout embryonic development and in adulthood in rat. Immunocytochemical analysis revealed that SelT is mainly localized to the endoplasmic reticulum through a hydrophobic domain. PACAP and cAMP induced a rapid and long-lasting increase in SelT gene expression in PC12 cells, in a Ca(2+)-dependent manner. These results suggested a possible role of SelT in PACAP signaling during PC12 cell differentiation. Indeed, overexpression of SelT in PC12 cells provoked an increase in the concentration of intracellular Ca(2+) ([Ca(2+)](i)) that was dependent on the Sec residue. Conversely, SelT gene knockdown inhibited the PACAP-induced inc...Continue Reading

References

Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L A Greene, A S Tischler
Jan 1, 1993·Annual Review of Neuroscience·D J Anderson
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·M R BöslM M Taketo
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·J A WaschekW I Rodriguez
Jan 14, 1999·The American Journal of Physiology·S LamoucheN Yamaguchi
Aug 30, 2000·Lancet·M P Rayman
May 9, 2002·Molecular and Cellular Biology·Dolph L Hatfield, Vadim N Gladyshev
Feb 18, 2003·Molecular and Cellular Biology·Easwari KumaraswamyDolph L Hatfield
Mar 21, 2003·The New England Journal of Medicine·Laurent TaupenotDaniel T O'Connor
Apr 18, 2003·Human Molecular Genetics·Nathalie PetitPascale Guicheney
May 31, 2003·Science·Gregory V KryukovVadim N Gladyshev
Aug 14, 2003·Gene Expression Patterns : GEP·Christine ThisseAlain Lescure
Nov 18, 2003·Molecular Biology of the Cell·Stéphane GasmanMarie-France Bader
Dec 31, 2003·Molecular Biology of the Cell·Hwa-Young Kim, Vadim N Gladyshev
Dec 31, 2003·The Journal of Cell Biology·Yun Li, Patricia Camacho
Aug 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tamaki MabuchiSeiji Ito
May 10, 2005·Journal of Cellular Physiology·Yi ZhengXun Shen
Jul 21, 2005·The European Journal of Neuroscience·R ThimmapayaV E Scott
Dec 2, 2005·The Journal of Biological Chemistry·Andrew D FergusonJohann Deisenhofer
May 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Veda Diwadkar-NavsariwalaAlan M Diamond

❮ Previous
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Citations

Apr 29, 2009·Cellular and Molecular Life Sciences : CMLS·M A Reeves, P R Hoffmann
Apr 25, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Perrine CastetsValérie Allamand
May 26, 2009·Molecules and Cells·Youn Wook ChungIck Young Kim
May 23, 2012·Biochemical Genetics·Mohamed E Moustafa, Hussien A Antar
Mar 23, 2010·Biological Trace Element Research·Wayne Chris Hawkes, Zeynep Alkan
Jun 4, 2013·Biological Trace Element Research·Mengyao GuoGuanghong Xie
Sep 15, 2009·Antioxidants & Redox Signaling·Valentina A ShchedrinaVadim N Gladyshev
Jan 11, 2012·Antioxidants & Redox Signaling·Anne RöselerKatja Becker
Nov 26, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Aniruddha SenguptaDolph L Hatfield
Aug 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Benjamin S WeeksDeborah Cooperstein
Jan 22, 2013·Biochimica Et Biophysica Acta·Hai-Dong YaoShi-Wen Xu
Sep 30, 2014·Current Opinion in Chemical Biology·Norman Metanis, Donald Hilvert
Jul 1, 2014·Biological Trace Element Research·Matthew W PittsMarla J Berry
Apr 30, 2015·Nutrients·Carina BenstoemChristian Stoppe
Jan 19, 2016·Biological Trace Element Research·Jia-Ping LiMeng-Yao Guo
Jan 12, 2012·Mutation Research·Lynnette R FergusonAlice H Wang
Mar 17, 2009·Biochimica Et Biophysica Acta·Alain LescureValérie Allamand
Sep 16, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A C PappasG Zervas
Oct 31, 2014·Thrombosis and Haemostasis·A H Rose, P R Hoffmann
Aug 19, 2015·Biological Trace Element Research·Mengyao GuoGanzhen Deng
Sep 1, 2015·Biological Trace Element Research·Jia-Qiang HuangXinGen Lei
Jul 5, 2012·Molecular Nutrition & Food Research·Stéphane TanguyFrançois Boucher
Mar 29, 2014·IUBMB Life·Roshan PillaiFrederick P Bellinger
Jul 15, 2015·Antioxidants & Redox Signaling·Jun Liu, Sharon Rozovsky
Jul 25, 2009·The Biochemical Journal·Frederick P BellingerMarla J Berry
Jul 30, 2014·Free Radical Biology & Medicine·S PenglaseS Ellingsen
Oct 30, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Wenbo ChenHaiyan Dong
Jan 14, 2017·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Larissa LagoGiselle Cerchiaro
May 21, 2013·Journal of Lipid Research·Choon Young Kim, Kee-Hong Kim
Nov 1, 2016·Molecular Neurobiology·Matthieu T CastexAnthony Falluel-Morel
Feb 11, 2016·Nutrients·Ashley N Ogawa-WongLucia A Seale
Nov 11, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Henry A Spiller
May 15, 2018·Antioxidants·Evangelos ZoidisGeorgios P Danezis
Apr 19, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alex B AddinsallNicole Stupka
May 16, 2019·The Journal of Experimental Biology·Rosa MazzaMaria Carmela Cerra
Nov 5, 2013·Metallomics : Integrated Biometal Science·Marco RomanCarlo Barbante
Sep 21, 2017·EMBO Reports·Abdallah HamiehIsabelle Lihrmann
Jul 6, 2014·Physiological Reviews·Vyacheslav M LabunskyyVadim N Gladyshev

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