Selenoproteins in bladder cancer

Clinica Chimica Acta; International Journal of Clinical Chemistry
Edyta Reszka

Abstract

Selenoproteins with genetically encoded selenium (Se) are very important in response to oxidative stress, redox balance and regulation of various metabolic and developmental processes. Although increased circulating Se has been associated with 33% risk reduction of bladder cancer, there are little data on selenoprotein expression at the protein and genetic level from both human and animal studies. Data from the Mammalian Gene Collection (MGC) Project clearly showed that highest mRNA expression in human urinary epithelium for TRXR1 (thioredoxin reductase 1), GPX1 (glutathione peroxidase 1), SEP15 (15 kDa selenoprotein), SELT (selenoprotein T) and SEPW1 (selenoprotein W1). Although bladder tumor has been characterized by increased Se, GPX and TRXR activity, circulating Se and GPX was interestingly decreased in these cancer patients. As such, selenoprotein expression in urinary epithelium may be involved in bladder cancer (development, progression and recurrence) and may play a significant role in chemotherapeutic intervention. Despite these findings, the role of selenoproteins in bladder cancer has rarely been investigated and the significance of selenoproteins in normal and malignant uroepithelium remains poorly understood.

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Citations

Oct 10, 2013·Mutagenesis·Satish GuptaAnna Jakubowska
Mar 1, 2016·Environmental and Molecular Mutagenesis·Sung Gu HanC Gary Gairola
Jan 5, 2014·Chemical Research in Toxicology·Simona ConstantinescuNiko Beerenwinkel
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May 28, 2020·Cancers·Edyta ReszkaZbigniew Jabłonowski
May 19, 2019·Science China. Life Sciences·Fanshuang ZhangYouhe Gao

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