Selenosartans: novel selenophene analogues of milfasartan and eprosartan

Bioorganic & Medicinal Chemistry Letters
Rebecca L GrangeCarl H Schiesser

Abstract

A series of selenophene analogues of the thiophene-containing antihypertensives milfasartan and eprosartan were prepared and tested for AT(1) receptor antagonist properties. All four selenophene compounds proved to be potent AT(1) receptor antagonists, with pK(B) estimates indicating that these selenides are at least as effective as the thiophene parent compounds at blocking AT(1) receptor mediated responses. These results reveal that replacement of sulfur with selenium in thiophene-containing sartans does not interfere with sartan activity.

References

Nov 4, 2005·Drugs·Gayle W Robins, Lesley J Scott

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Citations

Mar 30, 2011·Journal of Medicinal Chemistry·Jason A WilesMilind Deshpande
Nov 15, 2013·Journal of Pharmaceutical Sciences·Izabela MuszalskaAnna Jelińska
Apr 18, 2012·Journal of Pharmacological and Toxicological Methods·Nitya JaniChristine E Wright
Mar 31, 2011·Organic & Biomolecular Chemistry·Sara H KyneLouis Fensterbank
Oct 4, 2011·Chemical Communications : Chem Comm·Nichole P H TanNitya V Jani
Jan 12, 2010·Chemical Communications : Chem Comm·Maree K Staples, Carl H Schiesser
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Eduarda Santa-HelenaCarla Amorim Neves Gonçalves
Aug 9, 2020·Life Sciences·Eduarda Santa-HelenaLuiz Eduardo Maia Nery
Aug 26, 2010·Chemical Reviews·Deevi BasavaiahSatpal Singh Badsara
Sep 4, 2021·Beilstein Journal of Organic Chemistry·Tania XavierMarc Presset
Nov 13, 2010·Bioorganic & Medicinal Chemistry·Prashant NaikMange Ram Yadav

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