Selenylation modification: enhancement of the antioxidant activity of a Glycyrrhiza uralensis polysaccharide

Glycoconjugate Journal
Ke-Xun LianXin-Li Gu

Abstract

Selenium (Se) is an essential trace element for human beings and many other forms of life. Organic selenium from natural foods has greater bioavailability and is safer than inorganic selenium species. In this article, the structural properties and antioxidant activities of a Glycyrrhiza uralensis polysaccharide (GUP) after selenylation modification were investigated. The GUP was extracted by water decoction and ethanol precipitation and purified via protein elimination using the trichloroacetic acid method and column chromatography. The purified product was subsequently modified by the nitric acid-sodium selenite (HNO3-Na2SeO3) method. The selenized GUP (SeGUP) product was characterized by Fourier transform-infrared (FT-IR) spectroscopy, and its thermal stability, particle size, and antioxidant activities were investigated. FT-IR analysis indicated that the selenium in SeGUP existed mainly as O-Se-O. The thermal stability and particle size of SeGUP differed significantly from those of GUP. Moreover, compared to GUP, SeGUP exhibited greater antioxidant activities in vitro and in vivo. These results indicate that selenylation modification significantly enhances the antioxidant activity of SeGUP, increasing its potential for appli...Continue Reading

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Citations

Jun 2, 2020·Food & Function·Ning ZhouXiaoling Liu
Feb 18, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Houpan SongQinghua Peng
Dec 17, 2018·Carbohydrate Polymers·Jing LiKaoshan Chen
Jan 19, 2021·International Journal of Biological Macromolecules·Wanwen ChenWenshui Xia
Apr 23, 2021·International Journal of Biological Macromolecules·Zelalai SimayiNigary Yadikar
Nov 30, 2021·Biological Trace Element Research·Wen-Xia DuanMeng-Yuan Zhang

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Methods Mentioned

BETA
ELISA
gel filtration
MDA

Software Mentioned

DTS5

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