Self [3 + 4] Cycloadditions of Isatin N, N'-Cyclic Azomethine Imine 1,3-Dipole with N-( o-Chloromethyl)aryl Amides

The Journal of Organic Chemistry
Qiaomei JinShihe Hu

Abstract

A [3 + 4] annulation of isatin N, N'-cyclic azomethine imine 1,3-dipole 1 with in situ-generated aza-oQMs has been established for the synthesis of spirooxindole seven-membered scaffolds. These highly functionalized scaffolds were assembled in moderate to good yields (up to 96% yield). The novel spirooxindole scaffolds displayed moderate antitumor activities, which represented promising lead compounds for antitumor drug discovery.

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Citations

Jun 11, 2020·Chemistry, an Asian Journal·Karuppu SelvarajK C Kumara Swamy
Aug 23, 2019·The Journal of Organic Chemistry·Xiao-De AnJian Xiao
Sep 3, 2020·Organic Letters·Qing-Yun FangLi-Ming Zhao

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