Self-Adapting Hydrogel to Improve the Therapeutic Effect in Wound-Healing

ACS Applied Materials & Interfaces
Yongsan LiLei Tao

Abstract

Smart materials that can respond to multistimuli have been broadly studied. However, the smart materials that can spontaneously answer the ever-changing inner environment of living bodies have not been reported. Here, we report a strategy based on the dynamic chemistry to develop possible self-adapting solid materials that can automatically change shape without external stimuli, as organisms do. The self-adapting property of a chitosan-based self-healing hydrogel has been rediscovered since its dynamic Schiff-base network confers the unique mobility to that solid gel. As a result, the hydrogel can move slowly, like an octopus climbing through a narrow channel, only following the natural forces of surface tension and gravity. The fascinating self-adapting feature enables this hydrogel as an excellent drug carrier for the in vivo wound treatment. In a healing process of the rat-liver laceration, this self-adapting hydrogel demonstrated remarkable superiority over traditional drug delivery methods, suggesting the great potential of this self-adapting hydrogel as a promising new material for biomedical applications. We believe the current research revealed a possible strategy to achieve self-adapting materials and may pave the way ...Continue Reading

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Citations

Apr 16, 2019·Advanced Healthcare Materials·Fei GaoHai Ming Fan
Aug 11, 2020·The Journal of International Medical Research·Fan YangLanyu Zhu
Jun 26, 2020·Frontiers in Bioengineering and Biotechnology·Xi ZhangRui Li
Aug 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Junpeng XuShan-Hui Hsu
Oct 20, 2018·Frontiers in Chemistry·Yi Liu, Shan-Hui Hsu
Oct 7, 2020·Polymers·Sheila Maiz-FernándezSenentxu Lanceros-Mendez
Mar 27, 2021·Chemistry : a European Journal·Han CuiJinghua Chen
May 29, 2021·Biomaterials Science·Yingxia YaoYa Liu
May 16, 2021·International Journal of Biological Macromolecules·Mianhong ChenHaiming Cheng
Jul 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yifan ZhangXiaoya Liu
Jul 19, 2021·Journal of Colloid and Interface Science·Xiaoyong QiuJingcheng Hao
Aug 11, 2021·ACS Nano·Yongping LiangBaolin Guo
Oct 13, 2021·ACS Biomaterials Science & Engineering·Yunyi BoYingna He
Jan 25, 2021·Journal of Biomedical Nanotechnology·Youming DengWeidong Liu

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