Self-adjuvanting photosensitizer nanoparticles for combination photodynamic immunotherapy.

Biomaterials Science
Guiqiang ZhangJiwei Cui

Abstract

Combination cancer immunotherapy that synergizes the advantages of multiple therapeutic agents has shown great potential in tumor treatment. Herein, we report the one-step assembly of therapeutic nanoparticles (NPs) to co-deliver photosensitizers and adjuvants for combination photodynamic therapy (PDT) and immunotherapy. The NPs are obtained via self-assembly of chlorin e6 (Ce6) and imidazoquinoline-based TLR7 agonists (IMDQ), which results in a high loading efficacy of 72.2% and 27.8% for Ce6 and IMDQ, respectively. Upon laser irradiation, the resulting NPs could not only effectively induce photodynamic immunogenic cancer cell death, but also elicit robust antitumor immunity, leading to significant inhibition of both primary and distant tumors in a bilateral tumor model. This study demonstrates the potential of self-assembled NPs in co-delivering multiple therapeutics for potential immunotherapy to enhance the antitumor efficacy.

References

Apr 20, 2006·Nature Reviews. Immunology·Luca GattinoniNicholas P Restifo
Feb 9, 2007·Nature Biotechnology·Chris Clarke, Mark J Smyth
Jan 29, 2010·Chemical Reviews·Jonathan F LovellGang Zheng
Dec 24, 2011·Nature·Ira MellmanGlenn Dranoff
Nov 16, 2012·Nature Reviews. Cancer·Dmitri V KryskoPeter Vandenabeele
May 11, 2013·Advanced Materials·Jiwei CuiFrank Caruso
Apr 22, 2015·The New England Journal of Medicine·Caroline RobertUNKNOWN KEYNOTE-006 investigators
Nov 8, 2015·Advanced Drug Delivery Reviews·Chaoliang HeXuesi Chen
Nov 1, 2016·Nature Reviews. Immunology·Lorenzo GalluzziGuido Kroemer
Oct 22, 2016·Biomaterials·Si-Yong QinXian-Zheng Zhang
Mar 24, 2018·Science·Antoni Ribas, Jedd D Wolchok
Jan 6, 2019·Nature Reviews. Drug Discovery·Jérôme Galon, Daniela Bruni
Jan 1, 2018·Nature Biomedical Engineering
Feb 2, 2020·Nature Reviews. Immunology·Darrell J Irvine, Eric L Dane
Oct 1, 2020·Biomaterials Science·Tongyi ShangBin Yang
Mar 23, 2021·ACS Applied Materials & Interfaces·Guiqiang ZhangMing Hu

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked
flow cytometry
transmission
scanning electron microscopy
fluorescence imaging
ELISA
dynamic light scattering
infrared spectroscopy
Fluorescence

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.