PMID: 2498950Jan 1, 1989Paper

Self-administration of cocaine on a progressive ratio schedule in rats: dose-response relationship and effect of haloperidol pretreatment

Psychopharmacology
D C RobertsG J Vickers

Abstract

Intravenous cocaine self-administration behavior in rats was investigated using a progressive ratio (PR) schedule of reinforcement. The first response on the lever each day produced a drug infusion, whereupon the requirements of the schedule escalated with each reinforcement until the behavior extinguished. The final ratio completed each day was found to be relatively stable, sensitive to changes in dose, and drastically reduced by pretreatment with haloperidol (0.05 mg/kg). We conclude that self-administration behavior of rats reinforced on a progressive ratio schedule can provide useful information about changes in the reinforcing efficacy of specific drugs.

References

Nov 1, 1978·Pharmacology, Biochemistry, and Behavior·J A BedfordM C Wilson
Jun 1, 1977·Pharmacology, Biochemistry, and Behavior·D C RobertsH C Fibiger
Apr 1, 1976·Pharmacology, Biochemistry, and Behavior·C E JohansonK Bonese
Oct 1, 1976·Pharmacology, Biochemistry, and Behavior·M Risner, B E Jones
Nov 1, 1973·Pharmacology, Biochemistry, and Behavior·M C Wilson, C R Schuster
Jan 1, 1981·Psychopharmacology·M E Risner, D L Silcox
May 1, 1980·Pharmacology, Biochemistry, and Behavior·D C RobertsH C Fibiger

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Citations

Jan 1, 1993·Psychopharmacology·A MarkouG F Koob
Nov 1, 1994·Psychopharmacology·D H LiM W Emmett-Oglesby
Jul 1, 1995·Psychopharmacology·A SmithD C Roberts
May 1, 1995·Psychopharmacology·S C AronsonL H Price
Aug 1, 1995·Psychopharmacology·A Smith, D C Roberts
Jul 12, 2002·Psychopharmacology·Anita J Bechtholt, Gregory P Mark
Jun 24, 2009·Psychopharmacology·Nicole L Schramm-SapytaCynthia M Kuhn
Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·T SuzukiS Yanaura
Jul 1, 1991·Pharmacology, Biochemistry, and Behavior·L E Markert, D C Roberts
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·E A LohD C Roberts
Apr 11, 1992·Pharmacology, Biochemistry, and Behavior·W F Crowder, C W Hutto
Jul 1, 1993·Pharmacology, Biochemistry, and Behavior·R Y DepoortereM W Emmett-Oglesby
Apr 1, 1995·Pharmacology, Biochemistry, and Behavior·C A JonesA Poling
Mar 17, 2004·Neuroscience and Biobehavioral Reviews·Drake Morgan, David C S Roberts
Mar 5, 1997·European Journal of Pharmacology·L PulvirentiG F Koob
Apr 4, 1998·European Journal of Pharmacology·W M Meil, M D Schechter
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·C BelzungR Hen
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·N K Mello, J H Mendelson

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