Self-administration of the synthetic cathinone MDPV enhances reward function via a nicotinic receptor dependent mechanism

Neuropharmacology
Jean R GesteAdriaan W Bruijnzeel

Abstract

Methylenedioxypyrovalerone (MDPV) is an addictive synthetic drug with severe side effects. Previous studies have shown that MDPV has positive reinforcing properties. However, little is known about the effect of MDPV self-administration on the state of the brain reward system and the neuronal mechanisms by which MDPV mediates its effects. The goal of the present studies was to determine the effect of MDPV self-administration on reward function and the role of cholinergic neurotransmission in the reinforcing effects of MDPV. To study the effect of MDPV self-administration on the brain reward system, rats were prepared with intravenous catheters and intracranial self-stimulation electrodes (ICSS). For 10 days, the reward thresholds were assessed immediately before (23 h post prior session) and after 1 h of MDPV self-administration. The reward thresholds were decreased immediately after MDPV self-administration, which is indicative of a potentiation of brain reward function. The reward thresholds 23 h after MDPV intake gradually increased over time, which is indicative of anhedonia. Pretreatment with the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine decreased the self-administration of MDPV and completely prevent...Continue Reading

Citations

May 10, 2020·The Journal of Pharmacology and Experimental Therapeutics·Charlotte P MageeAnnette E Fleckenstein
Jun 17, 2020·Journal of Psychopharmacology·Michael B Gatch, Michael J Forster
Mar 27, 2019·Psychopharmacology·Ana Belen Lopez-Rodriguez, Maria-Paz Viveros
Aug 8, 2021·International Journal of Molecular Sciences·Laia Alegre-ZuranoOlga Valverde

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