Self-aggregated nanoparticles from linoleic acid modified carboxymethyl chitosan: Synthesis, characterization and application in vitro

Colloids and Surfaces. B, Biointerfaces
Yu-long Tan, Chen-Guang Liu

Abstract

The purpose of the present research work was to study the formation of linoleic acid (LA) modified carboxymethyl chitosan (LCC). Another objective was to evaluate effect of linoleic acid degree of substitution on loading capacity (LC), ADR loading efficiency (LE) and in vitro release profile of LCC nanoparticles. The hydrogel nanoparticles can be prepared using linoleic acid modified carboxymethyl chitosan (LACMCS) after the sonication. The critical aggregation concentration (CAC) of the self-aggregate of LA modified CMCS (LCC) was determined by measuring the fluorescence intensity of the pyrene as a fluorescent probe. The CAC values were in the range of 0.061-0.081mg/mL. Self-aggregated nanoparticles exhibited an increased LC and LE, decreased sustained release with an increasing ratio of the hydrophobic LA to hydrophilic CMCS. LCC nanoparticles loaded with ADR exerted in vitro anticancer activity against Hela cells that was comparable to the activity of free (non-entrapped in nanoparticles) ADR.

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Citations

Apr 5, 2011·Journal of Materials Science. Materials in Medicine·Yu-long Tan, Chen-Guang Liu
May 9, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Laxmi UpadhyayaRavi Prakash Tewari
Oct 5, 2010·Colloids and Surfaces. B, Biointerfaces·Jin LiangQiuhui Hu
Oct 2, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yingyue ZhangKathryn E Uhrich
Aug 18, 2009·Macromolecular Bioscience·Pranabesh DuttaJoykrishna Dey
May 15, 2016·Carbohydrate Polymers·Rafael de Oliveira PedroMiguel G Neumann
Aug 12, 2014·Biotechnology Advances·Yu YangMeiwan Chen
Oct 10, 2012·Carbohydrate Polymers·Laxmi UpadhyayaRavi Prakash Tewari
Jun 20, 2012·Carbohydrate Polymers·Warayuth SajomsangUracha Rungsardthong Ruktanonchai
Oct 31, 2009·Advanced Drug Delivery Reviews·Jae Hyung ParkIck Chan Kwon
Oct 8, 2016·Nanoscale·Kegang LiuPatrick Hunziker
Jan 14, 2017·Journal of Biomaterials Applications·Mazhar Ali RajaChen-Guang Liu
May 31, 2018·Medicinal Research Reviews·Marziyeh FathiYadollah Omidi
Aug 15, 2018·Journal of Drug Targeting·Sweet NaskarSuraj Sharma
Oct 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weiyu YangDanfei Huang
Feb 7, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Simo KalliolaMika Sillanpää

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