Self-aligning subatmospheric hybrid liquid junction electrospray interface for capillary electrophoresis

Electrophoresis
Jana KrenkovaFrantisek Foret

Abstract

We report a construction of a self-aligning subatmospheric hybrid liquid junction electrospray interface for CE eliminating the need for manual adjustment by guiding the capillaries in a microfabricated liquid junction glass chip at a defined angle. Both the ESI and separation capillaries are inserted into the microfabricated part until their ends touch. The distance between the capillary openings is defined by the angle between the capillaries. The microfabricated part contains channels for placement of the capillaries and connection of the external electrode reservoirs. It was fabricated using standard photolithographic/wet chemical etching techniques followed by thermal bonding. The liquid junction is connected to a subatmospheric electrospray chamber inducing the flow inside the ESI needle and helping the ion transport via aerodynamic focusing.

References

Mar 23, 2007·Journal of Chromatography. a·Jana KrenkováFrantisek Foret
Jul 11, 2008·Journal of Separation Science·Roman TomásFrantisek Foret
Oct 15, 2013·Journal of the American Society for Mass Spectrometry·Ioan MargineanRyan T Kelly
Mar 29, 2014·Mass Spectrometry Reviews·Gabor JarvasFrantisek Foret
Sep 27, 2014·Electrophoresis·Gabor JarvasAndras Guttman
Mar 5, 2015·Journal of Chromatography. a·Anna Tycova, Frantisek Foret

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Citations

Oct 27, 2016·Electrophoresis·Anna TýčováKarel Klepárník
Nov 11, 2017·Electrophoresis·Víctor González-RuizJulie Schappler
Sep 30, 2018·Journal of Separation Science·Anna Týčová, Karel Klepárník
Apr 30, 2019·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Javier Sastre TorañoGerhardus de Jong

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