Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles

Vaccines
Kenneth C McCulloughNicolas Ruggli

Abstract

Dendritic cells (DC) play essential roles determining efficacy of vaccine delivery with respect to immune defence development and regulation. This renders DCs important targets for vaccine delivery, particularly RNA vaccines. While delivery of interfering RNA oligonucleotides to the appropriate intracellular sites for RNA-interference has proven successful, the methodologies are identical for RNA vaccines, which require delivery to RNA translation sites. Delivery of mRNA has benefitted from application of cationic entities; these offer value following endocytosis of RNA, when cationic or amphipathic properties can promote endocytic vesicle membrane perturbation to facilitate cytosolic translocation. The present review presents how such advances are being applied to the delivery of a new form of RNA vaccine, replicons (RepRNA) carrying inserted foreign genes of interest encoding vaccine antigens. Approaches have been developed for delivery to DCs, leading to the translation of the RepRNA and encoded vaccine antigens both in vitro and in vivo. Potential mechanisms favouring efficient delivery leading to translation are discussed with respect to the DC endocytic machinery, showing the importance of cytosolic translocation from aci...Continue Reading

References

Sep 1, 1989·Immunology Today·C Janeway
Jul 1, 1997·Nature Biotechnology·D Fearon
Jul 13, 2000·Virology·W A Miller, G Koev
Sep 29, 2000·Pharmacology & Therapeutics·C Garcia-ChaumontJ Bolard
Jan 13, 2001·Current Opinion in Immunology·C Théry, S Amigorena
Sep 5, 2002·Reviews in Medical Virology·Jonathan O RaynerKurt I Kamrud
Mar 7, 2003·Nature·Sean D Conner, Sandra L Schmid
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Regina M KoflerChristian W Mandl
Jul 6, 2004·Immunological Reviews·William R HeathJose A Villadangos
Jul 23, 2004·Expert Opinion on Biological Therapy·Steve Pascolo
Aug 18, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Luc Wasungu, Dick Hoekstra
Sep 9, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haliza Katas, H Oya Alpar
Oct 3, 2006·Human Vaccines·Johanna A C SchalkTjeerd G Kimman
Feb 27, 2007·International Immunopharmacology·Yan KongYingying Le
Mar 31, 2007·The Journal of Biological Chemistry·Satoshi Uematsu, Shizuo Akira
Sep 20, 2007·Nature Immunology·Peter E Jensen
Nov 30, 2007·The EMBO Journal·Nuno Rocha, Jacques Neefjes
Feb 6, 2008·Current Opinion in Immunology·Sven Burgdorf, Christian Kurts
May 15, 2008·Biomedical Materials·Hu-Lin JiangChong-Su Cho
Jun 28, 2008·Current Opinion in Cell Biology·Guillaume van NielWillem Stoorvogel
Jul 22, 2008·Nature Reviews. Immunology·Jatin M VyasHidde L Ploegh
Sep 6, 2008·Developmental and Comparative Immunology·Kenneth C McCullough, Artur Summerfield
Nov 13, 2008·Expert Reviews in Molecular Medicine·Gregory J AtkinsBrian J Sheahan
Dec 17, 2008·Annals of the New York Academy of Sciences·Taro Kawai, Shizuo Akira
Apr 10, 2009·Advanced Drug Delivery Reviews·Kenneth Alan Howard
Aug 22, 2009·Nature Reviews. Molecular Cell Biology·Alexander Sorkin, Mark von Zastrow
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Roger Belizaire, Emil R Unanue
Nov 10, 2009·Cellular and Molecular Life Sciences : CMLS·F Said HassaneBernard Lebleu
Jan 19, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hidetaka AkitaHideyoshi Harashima

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Citations

May 31, 2016·Current Opinion in Immunology·Jeffrey B Ulmer, Andrew J Geall
Nov 26, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Thomas DémoulinsKenneth C McCullough
Jul 14, 2017·Expert Review of Vaccines·Carlo IavaroneJeffrey B Ulmer
Dec 14, 2019·Glycoconjugate Journal·Eugenia M RapoportNicolai V Bovin
Apr 15, 2016·Therapeutic Delivery·Andreas M ReichmuthDaniel Blankschtein
Jan 27, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Wei HeNicholas O Fischer
Jan 19, 2021·Advanced Healthcare Materials·William HoXiaoyang Xu
Feb 27, 2021·Molecular Cancer·Lei MiaoLeaf Huang
Sep 25, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Thomas DémoulinsKenneth C McCullough
Dec 21, 2018··G. WunderlinchC. F. M. Menck

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Methods Mentioned

BETA
nuclear translocation

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