Self-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy.

Drug Delivery
Yun LuShaoZhi Fu

Abstract

Dihydroartemisinin (DHA) is a potent anti-cancer drug that has limited clinical applications due to poor water solubility and low bioavailability. We designed a biodegradable poly(ethylene glycol) methyl ether-poly(ε-caprolactone) (MPEG-PCL) micelle carrier for DHA using the self-assembly method. The DHA/MPEG-PCL nanoparticles were spherical with an average particle size of 30.28 ± 0.27 nm, and released the drug in a sustained manner in aqueous solution. The drug-loaded nanoparticles showed dose-dependent toxicity in HeLa cells by inducing cycle arrest and apoptosis. Furthermore, compared to free DHA, the DHA/MPEG-PCL nanoparticles showed higher therapeutic efficacy and lower toxicity in vivo, and significantly inhibited tumor growth and prolonged the survival of tumor-bearing nude mice. In addition, the tumor tissues of the DHA/MPEG-PCL-treated mice showed a marked decline in the in situ expression of proliferation and angiogenesis markers. Taken together, the self-assembled DHA/MPEG-PCL nanoparticles are a highly promising delivery system for targeted cancer treatment.

References

Nov 3, 2004·Cancer Research·Omid C FarokhzadRobert Langer
Jul 2, 2009·Pharmaceutical Research·MaLing GouZhiYong Qian
Nov 26, 2009·International Journal of Pharmaceutics·XiuLing ZhengZhiYong Qian
Oct 23, 2010·Advanced Drug Delivery Reviews·Sarbari Acharya, Sanjeeb K Sahoo
Feb 22, 2012·Biochemical Pharmacology·Chris Zhiyi ZhangPaul Bo San Lai
Sep 17, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Qian SunShyh-Ming Kuo
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Mar 12, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Yanxue LiuLuying Wang
Dec 28, 2018·International Journal of Nanomedicine·Min WuJingBo Wu
Jan 3, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Li WangCong Wei
Jan 23, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hui LiYajing Sun
Apr 21, 2019·International Journal of Biological Macromolecules·Robin KumarAmulya K Panda
May 14, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jing-Jing LiuRui-Jun Ju
Mar 11, 2019·ACS Biomaterials Science & Engineering·Yu WangShaoZhi Fu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis