Self-assembled gemcitabine-gadolinium nanoparticles for magnetic resonance imaging and cancer therapy

Acta Biomaterialia
Lele LiDaniel S Kohane

Abstract

Nanoparticles with combined diagnostic and therapeutic functions are promising tools for cancer diagnosis and treatment. Here, we demonstrate a theranostic nanoparticle that integrates an active gemcitabine metabolite and a gadolinium-based magnetic resonance imaging agent via a facile supramolecular self-assembly synthesis, where the anti-cancer drug gemcitabine-5'-monophosphate (a phosphorylated active metabolite of the anti-cancer drug gemcitabine) was used to coordinate with Gd(III) to self-assemble into theranostic nanoparticles. The formulation exhibits a strong T1 contrast signal for magnetic resonance imaging of tumors in vivo, with enhanced retention time. Furthermore, the nanoparticles did not require other inert nanocarriers or excipients and thus had an exceptionally high drug loading (55 wt%), resulting in the inhibition of MDA-MB-231 tumor growth in mice. Recent advances in nanoparticle-based drug delivery systems have spurred the development of "theranostic" multifunctional nanoparticles, which combine therapeutic and diagnostic functionalities in a single formulation. Developing simple and efficient synthetic strategies for the construction of nanotheranostics with high drug loading remains a challenge. Here, we...Continue Reading

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Citations

Dec 17, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Sandeep K Mishra, S Kannan
Jan 23, 2019·Pharmaceutical Nanotechnology·Funmilola A Fisusi, Emmanuel O Akala
Oct 18, 2016·Topics in Magnetic Resonance Imaging : TMRI·Marie-France PenetZaver M Bhujwalla
Feb 20, 2020·Current Pharmaceutical Design·Tatielle do NascimentoEduardo Ricci Júnior
May 24, 2016·Advanced Materials·Qian LiuDaniel S Kohane
Nov 7, 2019·Pharmaceutics·Kamalika SamantaSubhash C Chauhan
Nov 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chuanqing Lan, Shulin Zhao
Apr 25, 2020·Frontiers in Chemistry·Małgorzata ŚwiętekDaniel Horák
Jun 20, 2021·Advanced Science·Jiating XuYujie Fu

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