Self-Assembled Metal-Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles

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Quinn A BesfordFrank Caruso

Abstract

Interfacial self-assembly is a powerful organizational force for fabricating functional nanomaterials, including nanocarriers, for imaging and drug delivery. Herein, the interfacial self-assembly of pH-responsive metal-phenolic networks (MPNs) on the liquid-liquid interface of oil-in-water emulsions is reported. Oleic acid emulsions of 100-250 nm in diameter are generated by ultrasonication, to which poly(ethylene glycol) (PEG)-based polyphenolic ligands are assembled with simultaneous crosslinking by metal ions, thus forming an interfacial MPN. PEG provides a protective barrier on the emulsion phase and renders the emulsion low fouling. The MPN-coated emulsions have a similar size and dispersity, but an enhanced stability when compared with the uncoated emulsions, and exhibit a low cell association in vitro, a blood circulation half-life of ≈50 min in vivo, and are nontoxic to healthy mice. Furthermore, a model anticancer drug, doxorubicin, can be encapsulated within the emulsion phase at a high loading capacity (≈5 fg of doxorubicin per emulsion particle). The MPN coating imparts pH-responsiveness to the drug-loaded emulsions, leading to drug release at cell internalization pH and a potent cell cytotoxicity. The results highl...Continue Reading

References

Mar 9, 2010·Angewandte Chemie·Angus P R JohnstonFrank Caruso
Jun 24, 2010·ACS Nano·Marek GrzelczakLuis M Liz-Marzán
Oct 27, 2010·AAPS PharmSciTech·Ketan HippalgaonkarViral Kansara
Dec 24, 2011·Journal of the American Chemical Society·Carl D WalkeyWarren C W Chan
Jan 11, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zohreh Amoozgar, Yoon Yeo
Jun 13, 2012·Nanoscale·Fernando C GiacomelliCristiano Giacomelli
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Mar 15, 2014·Advances in Colloid and Interface Science·Loretta Laureana del MercatoStefano Leporatti
Jul 6, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Horacio Cabral, Kazunori Kataoka
Mar 4, 2015·Journal of Proteomics·Daniela PozziAldo Laganà
May 27, 2015·Chemical Reviews·Bhushan S PattniVladimir P Torchilin
Jun 10, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·C FornagueraC Solans
Dec 25, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Karl Hörmann, Andreas Zimmer
Jan 23, 2016·Chemical Reviews·Guanying ChenParas N Prasad
Apr 23, 2016·Nature Chemistry·Yang YangChenxiang Lin
Jan 21, 2017·Journal of the American Chemical Society·Qianli ZouXuehai Yan
Feb 25, 2017·Nature Communications·Atul BhardwajFrank Wuest
Mar 14, 2017·Journal of the American Chemical Society·Tomoya SumaFrank Caruso
Jan 1, 2015·3 Biotech·Manjit JaiswalP K Sharma
May 17, 2017·Advanced Healthcare Materials·Yunlu DaiFrank Caruso
Oct 7, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Honghu ZhangDavid Vaknin
Jan 31, 2018·ACS Applied Materials & Interfaces·Pavel V CherepanovFrank Caruso

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Citations

Mar 6, 2019·Macromolecular Rapid Communications·Nayeleh DeirramGeorgina K Such
Feb 18, 2021·Chemical Society Reviews·Di WuJesse V Jokerst
Mar 13, 2020·Biomaterials·Apoorva SarodeSamir Mitragotri
Mar 19, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Bing-Pan ZhangLing-Shu Wan
May 22, 2021·Colloids and Surfaces. B, Biointerfaces·Yaping ZhangJianhua Li
Jun 20, 2021·Advanced Science·Jiating XuYujie Fu
Jul 22, 2021·ACS Applied Materials & Interfaces·Shiyao LiFrank Caruso
Jul 15, 2020·Journal of Agricultural and Food Chemistry·Di WuBin Zhou
May 1, 2019·ACS Applied Materials & Interfaces·Gan LinFrank Caruso
Nov 11, 2019·ACS Biomaterials Science & Engineering·Junling GuoHirotaka Ejima
Sep 14, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Qian WangJingcheng Hao
Sep 28, 2021·Journal of Agricultural and Food Chemistry·Di WuHongshan Liang

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