Self-assembled nano-architecture liquid crystalline particles as a promising carrier for progesterone transdermal delivery

International Journal of Pharmaceutics
Nazik A ElgindySalma M Mohyeldin

Abstract

The study aims to elaborate novel self-assembled liquid crystalline nanoparticles (LCNPs) for management of hormonal disturbances following non-invasive progesterone transdermal delivery. Fabrication and optimization of progesteroneloaded LCNPs for transdermal delivery were assessed via a quality by design approach based on 2(3) full factorial design. The design includes the functional relationships between independent processing variables and dependent responses of particle size, polydispersity index, zeta potential, cumulative drug released after 24h and ex-vivo transdermal steady flux. The developed nanocarrier was subjected to TEM (transmission electron microscope) for morphological elucidation and stability study within a period of three months at different storage temperatures. The cubic phase of LCNPs was successfully prepared using glyceryl monooleate (GMO) via the emulsification technique. Based on the factorial design, the independent operating variables significantly affected the five dependent responses. The cubosomes hydrodynamic diameters were in the nanometric range (101-386 nm) with narrow particle size distribution, high negative zeta potential ≥-30 mV and entrapment efficiency ≥94%. The LCNPs succeeded in sust...Continue Reading

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Jun 21, 2016·Biological & Pharmaceutical Bulletin·Yuri Ikeuchi-TakahashiHiraku Onishi
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Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tejashree WaghuleGautam Singhvi

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