Self-assembled nanomicelles using PLGA-PEG amphiphilic block copolymer for insulin delivery: a physicochemical investigation and determination of CMC values.

Journal of Materials Science. Materials in Medicine
Mohsen AshjariReza Rahmatolahzadeh

Abstract

Self-assembled nanomicelles can be used as synthetic biomaterials and colloidal carriers for poorly water-soluble drug delivery systems. Some of these micellar systems have been introduced in clinical trials and showed hopeful results relating to their therapeutic index in patients. Biodegradable nanomicelle was prepared from self-assembling amphiphilic block copolymer composed of poly(DL-lactic-co-glycolic acid) (PLGA) as a core and polyethylene glycol (PEG) as a corona. The PLGA-PEG block copolymer was first synthesized and characterized by FTIR, (1)H NMR, GPC and inherent viscosity measurements. The nanomicelle formed by PLGA-PEG block copolymer in the aqueous solution was characterized by dynamic light scattering, zeta potential, scanning electron microscopy (SEM) and fluorescence excitation and emission spectra of pyrene probe. The critical micelle concentration of obtained nanomicelle was about 0.006 mg/mL, with the size of about 160 nm and the zeta potential of -29 mV. Insulin-loaded PLGA-PEG nanomicelles were prepared by modified dialysis method and the physicochemical parameters of the micelles such as drug content, entrapment efficiency and in vitro drug release were characterized. The results showed that insulin was ...Continue Reading

References

Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·H S Yoo, T G Park
Jun 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·G M ZentnerS Weitman
Jul 11, 2003·Biomaterials·Béatrice HeurtaultJean-Pierre Benoit
Oct 16, 2003·International Journal of Pharmaceutics·Bumsang Kim, Nicholas A Peppas
Jan 28, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaeyoung LeeKilwon Cho
Apr 15, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang Yoo, Tae Gwan Park
Nov 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Geneviève GaucherJean-Christophe Leroux
Sep 21, 2007·Biochimica Et Biophysica Acta·Pouneh S PourhosseiniMohammad N Sarbolouki
Oct 22, 2008·Journal of Colloid and Interface Science·K Van ButseleC Jérôme
Jul 7, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Fabienne DanhierVéronique Préat
Jun 15, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Uttam KedarVilasrao Kadam
Jul 6, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Geneviève GaucherJean-Christophe Leroux
Nov 4, 2010·Journal of Colloid and Interface Science·Zhimei SongGuangxi Zhai
Dec 21, 2010·International Journal of Nanomedicine·Sanyuan Hu, Yangde Zhang

❮ Previous
Next ❯

Citations

May 17, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kumiko Sakai-KatoToru Kawanishi
Mar 1, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·N VargaI Dékány
Mar 25, 2016·Therapeutic Delivery·Vibhuti AgrahariAshim K Mitra
Apr 3, 2016·International Journal of Biological Macromolecules·Kaisar RazaO P Katare
Jul 1, 2015·International Journal of Pharmaceutics·Mônica Villa NovaMatthias G Wacker
Aug 24, 2016·ACS Applied Materials & Interfaces·Xuhan LiuWei Liu
Nov 23, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Javier Pérez QuiñonesOliver Brüggemann
Jun 26, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Runliang FengZhimei Song
Feb 1, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nikita MehraYasmin Sultana
Apr 13, 2021·Current Eye Research·Pankaj Kumar Sharma, Meenakshi Kanwar Chauhan
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Nidhi RavalRakesh K Tekade
Jun 18, 2021·Nanotechnology·Tzu-Han TsengChing-Yi Chen
Jun 29, 2021·Pharmaceutical Development and Technology·Tarek Metwally IbrahimHanan Mohammed El-Nahas
Jan 30, 2018·Journal of Agricultural and Food Chemistry·Javier Pérez QuiñonesCarlos Peniche Covas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.