Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

Advanced Healthcare Materials
Yunlu DaiFrank Caruso

Abstract

Therapeutic nanoparticles hold clinical promise for cancer treatment by avoiding limitations of conventional pharmaceuticals. Herein, a facile and rapid method is introduced to assemble poly(ethylene glycol) (PEG)-modified Pt prodrug nanocomplexes through metal-polyphenol complexation and combined with emulsification, which results in ≈100 nm diameter nanoparticles (PtP NPs) that exhibit high drug loading (0.15 fg Pt per nanoparticle) and low fouling properties. The PtP NPs are characterized for potential use as cancer therapeutics. Mass cytometry is used to quantify uptake of the nanoparticles and the drug concentration in individual cells in vitro. The PtP NPs have long circulation times, with an elimination half-life of ≈18 h in healthy mice. The in vivo antitumor activity of the PtP NPs is systematically investigated in a human prostate cancer xenograft mouse model. Mice treated with the PtP NPs demonstrate four times better inhibition of tumor growth than either free prodrug or cisplatin. This study presents a promising strategy to prepare therapeutic nanoparticles for biomedical applications.

References

Jan 5, 2005·Nature Reviews. Cancer·Bruce A Chabner, Thomas G Roberts
Sep 2, 2008·Nature Reviews. Drug Discovery·Mark E DavisDong M Shin
Aug 10, 2010·Advanced Drug Delivery Reviews·Jin XieXiaoyuan Chen
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos
Jan 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shanta DharOmid C Farokhzad
Feb 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Niels Holten-AndersenJ Herbert Waite
Jun 23, 2011·Accounts of Chemical Research·Jinjun ShiOmid C Farokhzad
Jul 24, 2012·Science·Jeffrey A Hubbell, Ashutosh Chilkoti
Sep 25, 2012·Advanced Drug Delivery Reviews·Christine E ProbstXiaohu Gao
Mar 8, 2013·Journal of the American Chemical Society·Jing ZhangXian-Zheng Zhang
Sep 26, 2013·Nature Reviews. Cancer·Caitriona HolohanPatrick G Johnston
Apr 5, 2014·Nature Communications·Kevin A CarterJonathan F Lovell
Oct 9, 2014·Angewandte Chemie·Tianmeng SunYounan Xia
Nov 26, 2014·Chemical Reviews·Eun-Kyung LimKwangyeol Lee
Jun 13, 2015·Journal of the American Chemical Society·Kuangda LuWenbin Lin
Oct 6, 2015·Advanced Drug Delivery Reviews·Harutaka MekaruFuyuhiko Tamanoi
Nov 12, 2015·Nature Communications·Bahman DelalatNicolas H Voelcker
May 21, 2016·Accounts of Chemical Research·Jiwei CuiFrank Caruso

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Citations

Jun 1, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Mengchen WuRui Liu
Sep 18, 2018·Angewandte Chemie·Md Arifur RahimFrank Caruso
Mar 15, 2019·Advanced Healthcare Materials·Jiwei CuiStephen J Kent
Jun 6, 2019·Chemical Society Reviews·Wei SangXiaoyuan Chen
Sep 3, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jingjing WangXiaoyuan Chen
Jul 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Li QiaoQingcong Wei
Oct 1, 2019·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Zhen YangXiaoyuan Chen
Mar 11, 2021·Biomaterials Science·Peng LiuWenhu Zhou
Jun 2, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Yeonwoo Jeong, Sung Min Kang
May 22, 2021·Colloids and Surfaces. B, Biointerfaces·Yaping ZhangJianhua Li
Jul 20, 2021·Advanced Drug Delivery Reviews·Zhejie ChenYitao Wang
Jul 30, 2021·Advanced Science·Yuezhou ZhangWei Huang
Nov 6, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Zhiliang GaoJiwei Cui
Feb 6, 2019·ACS Applied Materials & Interfaces·Gyeongwon YunFrank Caruso
Nov 11, 2019·ACS Biomaterials Science & Engineering·Junling GuoHirotaka Ejima
Jun 23, 2020·Accounts of Chemical Research·Jiajing ZhouFrank Caruso
Aug 23, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Jiwei CuiFrank Caruso

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