Self-assembled phospholipid-based phytosomal nanocarriers as promising platforms for improving oral bioavailability of the anticancer celastrol.

International Journal of Pharmaceutics
May S FreagOssama Y Abdallah

Abstract

Celastrol (CST) is a promising natural drug of herbal origin that gained a great interest in the recent years by virtue of its wide variety of pharmacological actions. Nowadays, CST is extensively studied as a natural anticancer surrogate with a potential activity against various types of cancers. However, CST suffers from many limitations that handicapped its clinical utility such as limited aqueous solubility and poor gastrointestinal absorption which resulted into its low oral bioavailability. This work spotlights, for the first time, development of self-assembled phytosomal nanocarriers (CST-PHY) for improving CST solubility and oral bioavailability. First CST-phospholipid complex was prepared by a simple solvent evaporation technique. Formation of CST-phospholipid complex was confirmed by differential scanning calorimetry (DSC), infrared spectroscopy (IR), powder X-ray diffraction (XRD) and partition coefficient determination. After dispersion into deionized water, CST-phospholipid complex was self-assembled to form CST-PHY. The optimized CST-PHY demonstrated a nanometric particle size of 178.4±7.07nm and a negative zeta potential of -38.7±3.61mV. Comparative in-vitro release study showed the ability of phytosomes to signi...Continue Reading

Citations

Jan 25, 2018·International Journal of Molecular Sciences·Botond PenkeLászló Vígh
Jan 31, 2020·Expert Opinion on Drug Delivery·Dina A HafezAhmed O Elzoghby
Jul 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Li QiaoQingcong Wei
Aug 21, 2020·Drug Delivery and Translational Research·Heba M K EbadaOssama Y Abdallah
Dec 12, 2018·Bio-medical Materials and Engineering·Jiajia QianGuoxi Li
Aug 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shuyu ZhanJeffrey Wang
Nov 12, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guihua Fang, Bo Tang
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Jan 20, 2021·ACS Biomaterials Science & Engineering·Hadeer M AbdelazizMay S Freag
Oct 11, 2020·Food Chemistry·Maria Del Pilar Garcia-MendozaPascale Subra-Paternault

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