Self-assembled reverse micelles in supercritical CO2 entrap protein in native state

Journal of the American Chemical Society
V Sai Vikrama Chaitanya, Sanjib Senapati

Abstract

Molecular dynamics simulations of random quaternary mixtures of protein-water-CO2-fluorosurfactants show the self-assembly of reverse micelles in supercritical carbon dioxide where the protein becomes entrapped inside the aqueous pool. Analyses show that the protein native state remains intact in the water pool. This is because of the bulk nature of the enclosed water that provides a suitable environment for the extracted protein. Results from ab initio calculations imply that the existing fluorosurfactants can be made more effective in stabilizing water-in-CO2 microemulsions by a partial hydrogenation in their tails. A Lewis acid-Lewis base interaction among CO2 and the surfactant tails enhances the stability of the aqueous droplets substantially. The study can help accelerate the search for surfactant process for environmentally benign applications in dense CO2.

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Citations

May 9, 2012·Journal of Agricultural and Food Chemistry·Laetitia M Bonnaillie, Peggy M Tomasula
Jun 3, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Frederic TewesFrank Boury
Aug 31, 2010·The European Physical Journal. E, Soft Matter·S AbelM Marchi
Feb 9, 2012·International Journal of Molecular Sciences·Alexandra L YverPeggy M Tomasula
Jun 21, 2011·The Journal of Chemical Physics·Jianhui Tian, Angel E García
Feb 10, 2011·The Journal of Chemical Physics·Anna Victoria MartinezJohn E Straub
Feb 28, 2015·The Journal of Physical Chemistry. B·Joshua L Bradley-ShawKen Lewtas
Aug 17, 2010·Journal of the American Chemical Society·Aneesh ChandranSanjib Senapati
May 10, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Muhan WangXiaoli Sun
Sep 28, 2016·Angewandte Chemie·Tian LuoZhonghua Wu
Jul 9, 2014·Soft Matter·Jianling ZhangBuxing Han
Jul 19, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Francesca Ingrosso, Manuel F Ruiz-López
Oct 22, 2009·The Journal of Physical Chemistry. B·Janamejaya Chowdhary, Branka M Ladanyi
Jul 24, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Yueju ZhaoGuanying Yang
Oct 30, 2010·The Journal of Physical Chemistry. B·Matteo SalvalaglioCarlo Cavallotti

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