Self-assembled structures formed during lipid digestion: characterization and implications for oral lipid-based drug delivery systems

Drug Delivery and Translational Research
Stephanie PhanBen J Boyd

Abstract

There is increasing interest in the use of lipid-based formulations for the delivery of poorly water-soluble drugs. After ingestion of the formulation, exposure to the gastrointestinal environment results in dispersion and digestion processes, leading to the production of amphiphilic digestion products that form self-assembled structures in the aqueous environment of the intestine. These structures are crucial for the maintenance of drug in a solubilized state prior to absorption. This review describes the structural techniques used to study such systems, the structures formed in assembled 'equilibrium' compositions where components are combined in expected ratios representative of the endpoint of digestion, structures formed using dynamic in vitro 'non-equilibrium' digestion models where the composition and hence structures present change over time and observations from ex vivo aspirated samples. Possible future directions towards an improved understanding of the structural aspects of lipid digestion are proposed.

References

Apr 13, 1979·Science·J S Patton, M C Carey
Jul 1, 1990·Pharmaceutical Research·J B DressmanK M Jarvenpaa
Jan 1, 1989·Annual Review of Biophysics and Biophysical Chemistry·M Caffrey
Mar 1, 1989·Canadian Journal of Physiology and Pharmacology·A B ThomsonM T Clandinin
Dec 18, 1989·Biochimica Et Biophysica Acta·Y GargouriR Verger
Mar 1, 1968·Journal of the American Oil Chemists' Society·D M Small
Jan 21, 1969·Biochimica Et Biophysica Acta·D M SmallD Chapman
Dec 1, 1965·Journal of the American Oil Chemists' Society·E S Lutton
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Müller
Feb 1, 1993·Pharmaceutical Research·T L RussellJ B Dressman
Jul 1, 1996·The American Journal of Physiology·M ArmandD Lairon
Aug 1, 1997·The American Journal of Physiology·J BorovickaM Fried
Mar 2, 1999·Journal of Colloid and Interface Science·J GustafssonH Ljusberg-Wahren
Dec 3, 1999·The American Journal of Clinical Nutrition·M ArmandD Lairon
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·T Gershanik, S Benita
Oct 18, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·C W Pouton
Aug 8, 2001·Advanced Drug Delivery Reviews·C J Porter, W N Charman
Aug 14, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·N H ZangenbergL Hovgaard
Sep 29, 2001·Advanced Drug Delivery Reviews·C J Porter, W N Charman
Sep 29, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·N H ZangenbergL Hovgaard
Nov 7, 2003·Journal of Pharmaceutical Sciences·Ping GaoMichael J Hageman
Mar 23, 2004·Pharmaceutical Research·Ann Marie KaukonenWilliam N Charman
Apr 15, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R Neslihan Gursoy, Simon Benita
Sep 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Greg A KossenaChristopher J H Porter
Oct 19, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Janne Ørskov ChristensenAnette Mullertz
Dec 25, 2004·Journal of Pharmaceutical Sciences·Greg A KossenaChristopher J H Porter
Jan 12, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Anan YaghmurOtto Glatter
Nov 1, 2005·Journal of Colloid and Interface Science·Johanna BornéAli Khan

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Citations

Mar 26, 2015·International Journal of Pharmaceutics·Tamer H Hassan, Karsten Mäder
Aug 9, 2016·Food & Function·David Julian McClementsBi-Cheng Wu
May 13, 2017·Metabolomics : Official Journal of the Metabolomic Society·Susanne B BreitkopfJohn M Asara
Dec 26, 2018·Food Chemistry·Peter J WildeMyriam M L Grundy
Nov 7, 2019·Advances in Colloid and Interface Science·Adam MacierzankaJulia Maldonado-Valderrama
Feb 24, 2021·AAPS PharmSciTech·Xingwang Zhang, Wei Wu
Mar 9, 2021·Frontiers in Pharmacology·Mohammed S AlqahtaniMuhammad Z Ahmad
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Anna C PhamBen J Boyd
Dec 10, 2016·ACS Applied Materials & Interfaces·Tahnee J DeningClive A Prestidge
Aug 26, 2021·Biochemical Society Transactions·Ben J Boyd, Andrew J Clulow
Oct 24, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Haiqiao WangPatrick T Spicer

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