Self-Assembled Thermoresponsive Polymeric Nanogels for 19 F MR Imaging

Biomacromolecules
Kristyna KolouchovaMartin Hruby

Abstract

Magnetic resonance imaging using fluorinated contrast agents (19F MRI) enables to achive highcontrast in images due to the negligible fluorine background in living tissues. In this pilot study, we developed new biocompatible, temperature-responsive, and easily synthesized polymeric nanogels containing a sufficient concentration of magnetically equivalent fluorine atoms for 19F MRI purposes. The structure of the nanogels is based on amphiphilic copolymers containing two blocks, a hydrophilic poly[ N-(2-hydroxypropyl)methacrylamide] (PHPMA) or poly(2-methyl-2-oxazoline) (PMeOx) block, and a thermoresponsive poly[ N(2,2difluoroethyl)acrylamide] (PDFEA) block. The thermoresponsive properties of the PDFEA block allow us to control the process of nanogel self-assembly upon its heating in an aqueous solution. Particle size depends on the copolymer composition, and the most promising copolymers with longer thermoresponsive blocks form nanogels of suitable size for angiogenesis imaging or the labeling of cells (approximately 120 nm). The in vitro 19F MRI experiments reveal good sensitivity of the copolymer contrast agents, while the nanogels were proven to be noncytotoxic for several cell lines.

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Citations

Jan 4, 2019·Nanoscale·Xiangjun HanKhashayar Farsad
Aug 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tong ShuMichael J Serpe
Jul 10, 2019·Future Medicinal Chemistry·Emilie HequetSophie Laurent
Dec 1, 2018·Magma·Daniel JirakMartin Hruby
May 30, 2020·Chemistry : a European Journal·Nicholas G TaylorFrank A Leibfarth
Mar 10, 2021·Chemical Society Reviews·Jia Lv, Yiyun Cheng
Apr 22, 2021·Biomacromolecules·Kristyna KolouchovaMartin Hruby
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Diana OleshchukVladimír Proks
Feb 21, 2019·Biomacromolecules·Jiří TrousilMartin Hrubý
Sep 29, 2021·Journal of Labelled Compounds & Radiopharmaceuticals·Moamen M SolimanHassan A Abd El-Rehim
Nov 4, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Nobuyuki MorimotoFrançoise M Winnik
Nov 12, 2021·Chemical Society Reviews·Marina MachtakovaKatharina Landfester
Nov 13, 2021·ACS Applied Materials & Interfaces·Hao WangHan Zhang
Nov 30, 2021·Gels·Tisana KaewruethaiJittima Amie Luckanagul

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