Self-assembling dendrimers

Science
S C ZimmermanS V Kolotuchin

Abstract

Hydrogen bond-mediated self-assembly is a powerful strategy for generating large structures from smaller subunits. The synthesis of molecules containing two isophthalic acid units covalently attached to a rigid aromatic spacer is described. By normal pairing of carboxylic acids into hydrogen-bonded dimers, these molecules self-assemble in organic solvents to form either a series of linear aggregates or a cyclic hexamer. These molecules were linked to the core of a family of polyether dendrimers, which caused the hexamer to be formed preferentially. The stability of the hexamer depended on the generation number of the dendrimer. The largest of these hydrogen-bonded macromolecular assemblies is roughly disk-shaped with a 9-nanometer diameter and a 2-nanometer thickness. Its size and molecular mass (34,000 daltons) are comparable to that of small proteins.

References

Jun 15, 1994·Analytical Chemistry·H G BarthC Jackson
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S C ZimmermanZ Zeng

❮ Previous
Next ❯

Citations

Jan 19, 2001·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·G De BelderF C De Schryver
Mar 23, 2001·Chemistry : a European Journal·W E AllenJ L Sessler
Jan 5, 2002·Chemistry : a European Journal·G M DykesG J Seeley
Jul 10, 2001·Angewandte Chemie·Leonard J. PrinsPeter Timmerman
Dec 20, 2002·Angewandte Chemie·Stuart J RowanJ Fraser Stoddart
Oct 9, 2002·Angewandte Chemie·Graham M DykesGordon J Seeley
Jul 4, 2012·Journal of Biosciences·Bidisha NandyPrabal K Maiti
Nov 1, 2005·Journal of Colloid and Interface Science·Lingyin LiYi Xie
Jan 9, 2001·Trends in Biotechnology·J Gariépy, K Kawamura
Sep 29, 2001·Advanced Drug Delivery Reviews·A T Florence, N Hussain
Nov 21, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·D TleugabulovaE Pentón
Mar 5, 2003·International Journal of Pharmaceutics·Khuloud T Al-JamalAlexander T Florence
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·I LebedevaM Vilenchik
Sep 3, 2011·Journal of the American Chemical Society·Alona UstinovBoris Rybtchinski
Sep 27, 2013·Journal of the American Chemical Society·Qixun ShiKenneth Wärnmark
Jan 23, 2009·Journal of the American Chemical Society·Jia LuoJian Pei
Aug 27, 2009·Journal of the American Chemical Society·Naoki TomimasuAkira Harada
Nov 13, 2009·Journal of the American Chemical Society·Stephan A SchmidLaura M Herz
Feb 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Michael J Serpe, Stephen L Craig
Mar 9, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Hai-Feng Ji, Xiaohe Xu
Dec 2, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Luis R RiveraJosé M Rivera
Jul 26, 2008·Nature Nanotechnology·Darrell W Kuykendall, Steven C Zimmerman
Jul 26, 2008·Nature Nanotechnology·Elamprakash N SavariarS Thayumanavan
Jan 25, 2011·Nature Nanotechnology·Elisha KriegBoris Rybtchinski
Feb 28, 2007·Physical Chemistry Chemical Physics : PCCP·Wenyong DongYu Liu
May 8, 2009·Chemical Society Reviews·L Andrew LyonAshlee St John
Aug 18, 2010·Chemical Communications : Chem Comm·Gabor BorzsonyiHicham Fenniri
Jul 26, 2011·Chemical Communications : Chem Comm·Chiyoung ParkChulhee Kim
Jan 18, 2006·Journal of Biomaterials Science. Polymer Edition·Hu Yang, Weiyuan John Kao
May 16, 2014·Nanomedicine·Ariane TschicheRainer Haag
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey D HartgerinkSamuel I Stupp
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jean M J Fréchet
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Johannes A A W ElemansRoeland J M Nolte
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·François Diederich, Béatrice Felber
Mar 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Perry S CorbinSteven C Zimmerman
Apr 26, 2008·Journal of Fluorescence·Issam OueslatiMário N Berberan-Santos
Jul 17, 2014·Chemical Communications : Chem Comm·Jiatao YanAfang Zhang
Oct 17, 2014·The Journal of Chemical Physics·Taraknath MandalPrabal K Maiti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.