Self-assembling peptide-etoposide nanofibers for overcoming multidrug resistance.

Chemical Communications : Chem Comm
Li-Song ZhangZhi-Song Zhang

Abstract

We developed a new strategy to overcome the MDR of etoposide using self-assembling nanofibers. Compared with the original etoposide, the inhibitory activity of Nap-GFFpYK-etoposide1/2 against murine Lewis lung cancer or breast cancer cells was increased 10 times, and 20 times on these cells with artificially overexpressed MDR1. Our method to synthesize and separate etoposide isomers provides a new strategy for the modification of this drug.

References

Mar 10, 2010·Journal of Medicinal Chemistry·Christian ChéJean-Paul Castaigne
Jun 11, 2010·Chemistry & Biology·Yves PommierChristophe Marchand
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Citations

Sep 4, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Jacek K WychowaniecAlberto Saiani

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Methods Mentioned

BETA
NMR
transmission electron microscopy
Fluorescence

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