Self-Assembling Peptide Nanofibrous Hydrogel on Immediate Hemostasis and Accelerative Osteosis

Biomacromolecules
Min WuXiaojun Zhao

Abstract

The use of local agents to achieve hemostasis of bone that does not interfere with repair and recovery is a complex and emergency subject in surgery. In this study, the dual functional biodegradable self-assembling nanopeptide (SAP) RADA16-I was synthesized by solid phase synthesis and was shown to exhibit immediate hemostasis and accelerative osteosis. The RADA16-I showed good performance as a hemostatic agent, which was investigated by comparison with the effects of bone wax in the ilium bone defect model of New Zealand rabbits. The RADA16-I exhibited efficient function of bone regeneration in both radiographic analysis and histological examination, while the bone wax inhibited osteogenesis. Moreover, in in vivo experiment, the RADA16-I was shown to exhibit excellent biocompatibility, while the group with bone wax showed a severe inflammatory response at the interface with bone. Thus, the RADA16-I is proven to be an excellent biocompatible material with effective dual function of hemostasis and osteosis.

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Citations

Aug 19, 2016·Advanced Drug Delivery Reviews·Handan AcarMatthew Tirrell
Mar 31, 2019·Biotechnology Journal·Ki Chan KimByeong Hee Hwang
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Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fanny d'OrlyéAnne Varenne
Nov 14, 2021·Biomaterials Research·Yong Kiel SungDong June Chung

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