Self-assembly of a catalytic multivalent peptide-nanoparticle complex

Journal of the American Chemical Society
Davide ZaramellaLeonard J Prins

Abstract

Catalytically active peptide-nanoparticle complexes were obtained by assembling small peptide sequences on the surface of cationic self-assembled monolayers on gold nanoparticles. When bound to the surface, the peptides accelerate the transesterification of the p-nitrophenyl ester of N-carboxybenzylphenylalanine by more than 2 orders of magnitude. The gold nanoparticle serves as a multivalent scaffold for bringing the catalyst and substrate into close proximity but also creates a local microenvironment that further enhances the catalysis. The supramolecular nature of the ensemble permits the catalytic activity of the system to be modulated in situ.

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Citations

Oct 17, 2013·ACS Nano·Edoardo LongoAlessandro Moretto
Jul 9, 2013·Nanoscale·Eric BusseronNicolas Giuseppone
Jan 23, 2013·International Journal of Molecular Sciences·Davide ZaramellaLeonard J Prins
Oct 31, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Christian FranceschiniLeonard J Prins
Nov 14, 2014·Journal of the Royal Society, Interface·Mailin MissonBo Jin
Apr 30, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Ming YuanFeng Zhang
Aug 17, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fabrizio MancinPaolo Scrimin
Nov 20, 2016·Biopolymers·Jason L HeierBeate Koksch
Sep 12, 2015·Chemical Communications : Chem Comm·Kwang Soo Lee, Jon R Parquette
Aug 13, 2015·Chemical Communications : Chem Comm·Serap YaparStefan Kubik
Jul 22, 2015·Chemical Communications : Chem Comm·Nishant SinghBeatriu Escuder
Jun 21, 2017·Chemical Communications : Chem Comm·A M GarciaS Marchesan
Mar 30, 2018·Chemical Society Reviews·O ZozuliaI V Korendovych
Jun 24, 2016·Organic & Biomolecular Chemistry·Cristian PezzatoLeonard J Prins
Jun 9, 2018·Physical Chemistry Chemical Physics : PCCP·Miguel Peixoto de AlmeidaEulália Pereira
Sep 14, 2012·Chemical Society Reviews·Zeyuan DongJunqiu Liu
Dec 5, 2019·Organic & Biomolecular Chemistry·Alexander J Kleinsmann, Boris J Nachtsheim
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Jan 21, 2021·Journal of the American Chemical Society·Minju KimBartosz A Grzybowski
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea CaporaleMichele Saviano
Apr 4, 2021·International Journal of Molecular Sciences·Sutapa DuttaGiorgia Brancolini

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