Self-assembly of amphiphilic tripeptides with sequence-dependent nanostructure

Biomaterials Science
Jugal Kishore SahooMatthew J Webber

Abstract

Supramolecular chemistry enables the creation of a diversity of nanostructures and materials. Many of these have been explored for applications as biomaterials and therapeutics. Among them, self-assembling peptides have been broadly applied. The structural diversity afforded from the library of amino acid building blocks has enabled control of emergent properties across length-scales. Here, we report on a family of amphiphilic tripeptides with sequence-controlled nanostructure. By altering one amino acid in these peptides, we can produce a diversity of nanostructures with different aspect-ratio and geometry. Peptides that produce high aspect-ratio structures can physically entangle to form hydrogels, which support cell viability in culture. Importantly, in comparison to many other short self-assembling peptide biomaterials, those reported here form filamentous nanostructures in the absence of typical secondary structures (i.e., β-sheet). Thus, we have illustrated a facile way to obtain versatile biomaterials with different nanostructural morphology from short and defined peptide sequences.

References

Nov 27, 2001·Science·J D HartgerinkS I Stupp
Apr 26, 2003·Science·Meital Reches, Ehud Gazit
Oct 2, 2003·Nature Biotechnology·Shuguang Zhang
Nov 2, 2005·Chembiochem : a European Journal of Chemical Biology·Radhakrishnan MahalakshmiPadmanabhan Balaram
Mar 26, 2008·Chemical Society Reviews·Rein V Ulijn, Andrew M Smith
Jul 26, 2008·Nature Nanotechnology·Yan GengDennis E Discher
Nov 18, 2008·Acta Biomaterialia·Monica C Branco, Joel P Schneider
Apr 10, 2010·Journal of the American Chemical Society·E Thomas PashuckSamuel I Stupp
May 26, 2010·Chemical Society Reviews·Xiubo ZhaoJian R Lu
Jun 4, 2010·Chemical Society Reviews·Charlotte A E Hauser, Shuguang Zhang
Jun 18, 2010·Journal of the American Chemical Society·E Thomas Pashuck, Samuel I Stupp
Jan 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Charlotte A E HauserUlrich A Hauser
Nov 15, 2011·Chemical Communications : Chem Comm·John B Matson, Samuel I Stupp
Feb 22, 2012·Science·T AidaS I Stupp
Feb 5, 2014·Journal of Nanobiotechnology·Li ShangGerd Ulrich Nienhaus
Feb 18, 2014·Israel Journal of Chemistry·Matthew J WebberSamuel I Stupp
Apr 10, 2014·Chemical Communications : Chem Comm·Jugal Kishore SahooRein V Ulijn
Sep 10, 2014·Chemical Society Reviews·Scott Fleming, Rein V Ulijn
Apr 22, 2015·Chemical Communications : Chem Comm·Charalampos G PappasShuo Bai
Sep 9, 2015·Nature Biotechnology·Elvin BlancoMauro Ferrari
Dec 19, 2015·Nature Materials·Matthew J WebberRobert Langer
Mar 21, 2017·Biomaterials·Jie ZhouBing Xu
Sep 19, 2016·Bioengineering & Translational Medicine·Matthew J Webber
Nov 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·S MarchesanA V Vargiu

❮ Previous
Next ❯

Citations

Aug 15, 2017·Chemical Communications : Chem Comm·Yousef M Abul-HaijaRein V Ulijn
Aug 23, 2017·Chemical Society Reviews·Matthew J Webber, Robert Langer
Dec 20, 2019·Biomaterials Science·Amber M HilderbrandApril M Kloxin
Sep 15, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sijie Xian, Matthew J Webber
Jun 18, 2020·Frontiers in Bioengineering and Biotechnology·Seema GuptaPradeep Kumar
Jan 16, 2021·Advanced Drug Delivery Reviews·Matthew J Webber, E Thomas Pashuck
Apr 4, 2021·International Journal of Molecular Sciences·Peter J JervisPaula M T Ferreira
Nov 14, 2020·International Journal of Molecular Sciences·Qinsi XiongWei Han
Jul 9, 2018·ACS Biomaterials Science & Engineering·Rui ZhangBret D Ulery
Feb 14, 2020·Biomacromolecules·Kuljeet KaurJohn B Matson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved