Self-assembly of DNA-porphyrin hybrid molecules for the creation of antimicrobial nanonetwork

Journal of Photochemistry and Photobiology. B, Biology
Rina KumariProlay Das

Abstract

DNA derived well-controlled arrangement of porphyrins has emerged as promising hybrid nanostructures. Exceptional biocompatibility and DNA-directed surface addressability coupled with rich symmetry features of the porphyrin have made these hybrid nanostructures attractive candidates for potential biomedical and biotechnological applications. However, the noteworthy photophysical properties of porphyrin and related molecules when present in DNA based nanostructures are yet to be explored fully and should be a matter of intense research that may unearth a plethora of interesting applications of these nanostructures. Herein, we demonstrate the construction of novel self-assembled DNA-porphyrin hybrid nanonetworks that utilize the porphyrin core for antibacterial applications. Porphyrin derivative with four pendant NH2 groups was synthesized and conjugated with the 5'-PO4 of ss-DNA by solution phase phosphoramidation coupling reaction. The conjugation was followed by DNA hybridization mediated self-assembly to form DNA-porphyrin hybrid nanonetwork. The enhanced antimicrobial property of the nanonetwork was envisioned following light irradiation at relevant wavelength. In line with this, comparative antimicrobial activities against ...Continue Reading

Citations

Jul 26, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ncediwe TsolekileOluwatobi Samuel Oluwafemi
Nov 17, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Nidia Maldonado-CarmonaStéphanie Leroy-Lhez

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