Self-Assembly of Stable Nanoscale Platelets from Designed Elastin-like Peptide-Collagen-like Peptide Bioconjugates

Biomacromolecules
Jingya QinKristi L Kiick

Abstract

The self-assembly of nanostructures from elastin-like (poly)peptide (ELP) containing block copolymers has been a subject of intense investigation over decades. However, short synthetic ELPs have rarely been used due to their high inverse transition temperature; the use of short ELPs has largely been limited to polymer conjugates. Motivated by our previous work which successfully overcame this barrier by simply conjugating short ELPs with a triple-helix-forming collagen-like peptide, in this study, we further extend the ELP library to a series of ELPs equipped with aromatic residues and having sequences as short as four pentapeptide motifs. The resulting elastin-like peptide-collagen-like peptide (ELP-CLP) bioconjugates unexpectedly self-assembled into nanosized platelets likely by forming a bilayer structure. Given the previously demonstrated ability of many other CLP conjugates to target collagens and the potential for encapsulation of hydrophobic drugs in collapsed ELPs, these ELP-CLP nanoplatelets may offer similar opportunities for targeted delivery in biomedical and other arenas.

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Citations

Jul 10, 2019·Matrix Biology : Journal of the International Society for Matrix Biology·Arturo Ibáñez-FonsecaJosé Carlos Rodríguez-Cabello
Sep 2, 2020·Advanced Drug Delivery Reviews·Anastasia VarankoAshutosh Chilkoti
Dec 20, 2019·Biomacromolecules·Md Shahadat HossainDavoud Mozhdehi
Jul 13, 2021·ACS Biomaterials Science & Engineering·Diego López BarreiroCees M J Sagt
Sep 7, 2021·Biotechnology Progress·Graham Strauss, Piyush Koria
Oct 27, 2021·Expert Opinion on Drug Delivery·Lucas C DunsheeKristi L Kiick
Dec 24, 2021·Biomacromolecules·Md Shahadat HossainDavoud Mozhdehi

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