PMID: 2484632Jul 1, 1989Paper

Self-association of nucleotides. Effects of protonation and metal ion coordination

Biological Trace Element Research
Helmut Sigel

Abstract

The self-association of nucleosides decreases within the series adenosine greater than guanosine greater than inosine greater than cytidine approximately uridine. The same trend is observed for the corresponding nucleotides, though less pronounced, as the charge effect governs series like adenosine much greater than AMP2- greater than ADP3- approximately greater than ATP4-. Protonation of adenosine considerably reduces its self-stacking tendency: this is different with ATP4-, where a maximum is reached for H2(ATP)2- caused by additional ionic interactions in the [H2(ATP)]2(4-) dimer. Metal ion coordination may promote self-association, e.g., of ATP4- via (mainly) charge neutralization (Mg2+) and the formation of intermolecular bridges in dimeric stacks (Zn2+, Cd2+). These results allow definition of conditions with negligible self-association and thus the determination of the stability and structure of monomeric nucleotide complexes in aqueous solution, e.g., quantification of macrochelate formation in M(ATP)2- complexes. Some biological implications of the results are indicated.

References

Feb 21, 1973·Journal of the American Chemical Society·J L Dimicoli, C Hélène
Jan 16, 1984·European Journal of Biochemistry·M P Williamson, D H Williams

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Citations

May 16, 2020·Physical Chemistry Chemical Physics : PCCP·Huishu MaXiaoling Lei
Nov 1, 2005·Dalton Transactions : an International Journal of Inorganic Chemistry·Piotr KaczmarekMałgorzata Jezowska-Bojczuk
Feb 15, 2008·Bioinorganic Chemistry and Applications·Maria JaworskaMałgorzata Jezowska-Bojczuk
Aug 11, 2007·Journal of Inorganic Biochemistry·Ariel MuchaMałgorzata Jezowska-Bojczuk

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