Self-Cleaning, Thermoresponsive P (NIPAAm-co-AMPS) Double Network Membranes for Implanted Glucose Biosensors

Macromolecular Materials and Engineering
Ruochong FeiMelissa A Grunlan

Abstract

A self-cleaning membrane that periodically rids itself of attached cells to maintain glucose diffusion could extend the lifetime of implanted glucose biosensors. Herein, we evaluate the functionality of thermoresponsive double network (DN) hydrogel membranes based on poly(N-isopropylacrylamide) (PNIPAAm) and an electrostatic co-monomer, 2-acrylamido-2-methylpropane sulfonic acid (AMPS). DN hydrogels are comprised of a tightly crosslinked, ionized first network [P(NIPAAm-co-AMPS)] containing variable levels of AMPS (100:0-25:75 wt% ratio of NIPAAm:AMPS) and a loosely crosslinked, interpenetrating second network [PNIPAAm]. To meet the specific requirements of a subcutaneously implanted glucose biosensor, the volume phase transition temperature is tuned and essential properties, such as glucose diffusion kinetics, thermosensitivity, and cytocompatibility are evaluated. In addition, the self-cleaning functionality is demonstrated through thermally driven cell detachment from the membranes in vitro.

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Citations

Jan 18, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chuanrui ChenHuisheng Peng
Jan 24, 2021·Advanced Drug Delivery Reviews·Bhushan N KharbikarTejal A Desai
May 4, 2021·Advanced Healthcare Materials·Anna HerrmannUwe Schedler
Apr 23, 2019·Biomacromolecules·A Kristen MeansMelissa A Grunlan
Jun 18, 2019·ACS Macro Letters·A Kristen Means, Melissa A Grunlan

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