Self-crosslinking effect of chitosan and gelatin on alginate based hydrogels: Injectable in situ forming scaffolds

Materials Science & Engineering. C, Materials for Biological Applications
Ziba NaghizadehArash Khojasteh

Abstract

Injectable in situ forming hydrogels has great potential in tissue engineering. Simple and easy preparation of these hydrogels with low toxicity and stability is a great advantage. In the present study, two types of self-crosslinking in situ forming alginate based hydrogels with different formulation were synthesized, characterized and compared in order to introduce an optimal injectable scaffold in minimally invasive applications in tissue engineering. To this end, the hydrogels consist of oxidized alginate (AD), polyethylene glycol (PEG) and carboxymethyl chitosan (CMC) or gelatin (GEL) was synthesized. The hydrogels were assessed by many techniques including microscopy, spectroscopy, compressive analysis, injectability, rheological analysis and cell viability to ascertain hydrogel properties. In comparison with AD/PEG-GEL hydrogel, AD/PEG-CMC hydrogel showed a higher compressive modulus, viscosity and injection time, whereas AD/PEG-GEL hydrogel displayed a higher degree of crosslinking. Due to the rheological behavior of AD/PEG-CMC hydrogel, this composition was more suitable for the injectable application. The hydrogels, despite the composition, showed the ability to survive and proliferate mesenchymal stem cells based on c...Continue Reading

Citations

Apr 7, 2020·Biotechnology and Applied Biochemistry·AmirHossein BahmanpourMasoud Mozafari
Jul 25, 2019·AAPS PharmSciTech·Nermeen A Elkasabgy, Azza A Mahmoud
Sep 3, 2020·Tissue Engineering. Part B, Reviews·Jeremie D OliverRena N D'Souza
May 1, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Fatemeh MorshedlooMehri Ahmadian
Aug 27, 2019·Frontiers in Cardiovascular Medicine·Malebogo NgoepeThomas Franz
Mar 9, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoli KongJun Wu
Sep 15, 2019·International Journal of Pharmaceutics·Raya BushkalovaSophie Girod Fullana
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Syed Ahmed ShahMubeen Kousar
Jun 12, 2021·Colloids and Surfaces. B, Biointerfaces·Nandita SrivastavaAnirban Roy Choudhury

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