Sep 30, 1974

Self-damping mechanism in blood coagulation

Thrombosis Et Diathesis Haemorrhagica
Y NemersonJ Jesty


Two reactions of the extrinsic pathway of coagulation, the activations of Factor X and prothrombin, have been studied in purified systems and shown to be self-damping. Factor X was activated by the tissue factor-Factor VII complex, and prothrombin by two systems: the coagulant protein of Taipan venom, and the physiological complex of activated Factor X, Factor V, lipid, and calcium ions. In each case the yield of enzyme, activated Factor X or thrombin, is a function of the concentration of activator. These and other observations are considered as a basis for a control mechanism in coagulation.

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Mentioned in this Paper

Clotting Factor II Assay
Factor V
F2 gene
Calcium ion
Feedback - System Communication
Factor VIII Procoagulant Activity
Factor X

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