Self-destructive PEG-BODIPY nanomaterials for photodynamic and photothermal therapy

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Chaonan LiZhigang Xie

Abstract

Photoactive nanoparticles are an important platform for multimodal imaging and phototherapy of tumors. Herein, amphiphilic photosensitizers were made from boron dipyrromethene (BODIPY) and poly(ethylene glycol) (PEG2k) by using a thioketal linker, which is reactive oxygen species-responsive. The photosensitizers could form stable nanoparticles in aqueous solution. The resulting nanoparticles could simultaneously produce heat and reactive oxygen species upon irradiation to achieve combined photothermal and photodynamic therapy. The produced singlet oxygen could destroy the thioketal linker, and accelerate the destruction of nanoparticles. In addition, the near-infrared fluorescence and photoacoustic imaging ability of nanoparticles can reflect the biodistribution and destiny of nanoparticles. This work highlights the application of integrated diagnostic and therapeutic photosensitizers in carriers.

References

Mar 2, 2013·Chemical Society Reviews·Jianzhang ZhaoSong Guo
Jan 21, 2015·Chemical Reviews·Sasidharan Swarnalatha LuckyYong Zhang
Oct 16, 2015·Chemical Society Reviews·Jianzhang ZhaoFangfang Zhong
Jan 6, 2016·Nanoscale·Yiming ZhouZhifei Dai
Oct 8, 2016·Advanced Materials·Zhengqing GuoHuabing Chen
Aug 16, 2017·ACS Applied Materials & Interfaces·Wenhai LinZhigang Xie
Jan 9, 2018·Nanoscale·Layla Mohammad-HadiElnaz Yaghini
Mar 13, 2018·Chemical Society Reviews·Hyo Sung JungJong Seung Kim
Jun 12, 2018·Angewandte Chemie·Benjamin M LubyGang Zheng
Dec 7, 2018·ACS Applied Materials & Interfaces·Wei ZhangZhigang Xie
Jan 22, 2019·Angewandte Chemie·Mingying YangChuanbin Mao
Feb 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zheng RuanLifeng Yan
May 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pengfei SunWei Huang
Nov 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Duo SunNanfeng Zheng
Dec 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yongchao YanJianli Hua
Feb 7, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuting GaoChaobo Huang
Dec 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qi CaiPiaoping Yang
Mar 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yen-Chih Lai, Cheng-Chung Chang
Jun 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dong CuiKanyi Pu
Apr 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liang GuoPengfei Wang

❮ Previous
Next ❯

Citations

Mar 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Wenhai LinGang Han
Feb 22, 2021·European Journal of Medicinal Chemistry·Gan XuJian-Yong Liu
Aug 7, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chong MaZhigang Xie
Aug 19, 2020·ACS Applied Materials & Interfaces·Lin MeiJunxia Zhang
Jun 20, 2020·ACS Applied Materials & Interfaces·Chaonan LiZhigang Xie
Dec 7, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bowen JiangZhigang Xie

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence imaging
nanoprecipitation
nuclear magnetic resonance
dynamic light scattering
flow cytometry
Fluorescence

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.