Self-determinants in autoimmune demyelinating disease: changes in T- cell response specificity

Current Opinion in Immunology
V K TuohyA Ben-Nun

Abstract

Recent research developments support the following views regarding antigen recognition in autoimmune demyelinating disease: there may be no single autoimmune target protein; diverse peptide self-determinants from multiple myelin proteins can be recognized; target determinant epitopes may differ among individuals; and target epitope recognition can change with time during the course of disease.

References

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May 10, 2007·Nature Protocols·Ingunn M Stromnes, Joan M Goverman

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