Self-dissolving micropile array tips for percutaneous administration of insulin.

Journal of Materials Science. Materials in Medicine
Yukako ItoKanji Takada

Abstract

Two kinds of insulin were loaded into self-dissolving micropile array tip (following tip). Fully-loaded tip (f-tip) and partially-loaded tip (p-tip) were prepared using chondroitin sulfate for the percutaneous administration of insulin. One hundred micropiles were constructed on a 1.0 x 1.0 cm tip. The mean length of the micropile in a tip were 483.4 +/- 4.7 mum for the f-tip and 492.6 +/- 2.4 mum for the p-tip. The insulin content of the p-tip was 28.5% of that of the f-tip. The pharmacological efficiency of insulin loaded tip was evaluated in rat experiments by measuring their hypoglycemic effects. The maximum hypoglycemic effect of insulin was observed at 1.7 +/- 0.2 h for the f-tip and 1.5 +/- 0.2 h for the p-tip. Good dose-dependency was observed for the plasma glucose level vs. time curves. These results suggest the usefulness of p-tip as a percutaneous DDS of insulin.

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Citations

May 18, 2010·Diabetes Technology & Therapeutics·Keizo FukushimaKanji Takada
Sep 28, 2012·Diabetes Technology & Therapeutics·Yukako ItoKanji Takada
Nov 22, 2012·Journal of Drug Targeting·Jeong Woo LeeJung-Hwan Park
May 12, 2012·Advanced Drug Delivery Reviews·Yeu-Chun KimMark R Prausnitz
Jul 4, 2012·International Journal of Pharmaceutics·Yukako ItoKanji Takada
Jul 1, 2015·Pharmaceutical Development and Technology·Xingxing WuPing Ma
May 7, 2016·International Journal of Pharmaceutics·Yuqin QiuYunhua Gao
Aug 20, 2016·Journal of Biomedical Materials Research. Part a·I-Chi LeeMeng-Tsan Tsai
Dec 31, 2017·Drug Delivery and Translational Research·Tamara N TarboxRobert O Williams
Apr 23, 2010·Chemical & Pharmaceutical Bulletin·Yukako ItoKanji Takada
Apr 23, 2010·Biological & Pharmaceutical Bulletin·Yukako ItoKanji Takada
Mar 26, 2011·Pharmaceutical Research·Katarzyna MigalskaRyan F Donnelly
Apr 28, 2020·Drug Delivery and Translational Research·Marwa Hasanein Asfour
Jan 27, 2021·Drug Discovery Today·Alessandra T ZizzariRainer Riedl
Aug 1, 2021·Journal of Materials Science. Materials in Medicine·Rupali S Bhadale, Vaishali Y Londhe

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