Self-eating from an ER-associated cup.

The Journal of Cell Biology
Anne Simonsen, Harald Stenmark

Abstract

Since the first morphological description of autophagosomes in the early 1960s, two critical questions have been a matter of intense investigation and debate: what is the origin of the autophagosomal membrane and how is it formed? A study by Axe et al. (E.L. Axe, S.A. Walker, M. Manifava, P. Chandra, H.L. Roderick, A. Habermann, G. Griffiths, and N.T. Ktistakis. 2008. J. Cell Biol. 182:685-701) provides evidence that cup-shaped protrusions from the endoplasmic reticulum, named omegasomes, serve as platforms for autophagosome biogenesis in mammalian cells.

References

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Citations

Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marlène DreuxFrancis V Chisari
Apr 22, 2011·Journal of Virology·Jianhua LiZhenghong Yuan
Apr 11, 2012·International Journal of Molecular Sciences·Dalibor MijaljicaRodney J Devenish
Dec 18, 2013·Cell Research·Ryan C RussellKun-Liang Guan
Feb 19, 2010·Cellular and Molecular Life Sciences : CMLS·Gian Maria Fimia, Mauro Piacentini
Oct 3, 2013·Neurochemical Research·Gustavo J S PereiraSoraya S Smaili
Aug 8, 2012·The Journal of Cell Biology·Frank G A FaasRaimond B G Ravelli
Jul 5, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stéphanie De RechterDjalila Mekahli
Dec 3, 2014·Methods : a Companion to Methods in Enzymology·Ann-Katrin ThostTassula Proikas-Cezanne
Mar 24, 2009·Biochimica Et Biophysica Acta·Emanuel Campoy, María I Colombo
Jan 24, 2019·Cold Spring Harbor Perspectives in Biology·Patrick G NeedhamJeffrey L Brodsky
Jan 9, 2015·Journal of Cell Science·Tassula Proikas-CezanneOliver Kohlbacher
Apr 11, 2018·Molecular and Cellular Biology·Eunice Domínguez-MartínRicardo Escalante

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Methods Mentioned

BETA
GTPase

Related Concepts

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Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.