Self-emulsification of Lipidic Drug Delivery System in Pure Water and in Concentrated Glycerol Solution

AAPS PharmSciTech
Carole PlanchettePeter Laggner

Abstract

Self-emulsifying drug delivery systems (SEDDS), often intended for oral delivery, are normally explored in biorelevant aqueous media. The high complexity of these multi-component systems leaves the understanding of self-emulsification poor, hindering formulation rationalization. In this work, we aimed to fill this gap by studying the effects of glycerol on the self-emulsification of a ternary component formulation made of 20% w/w Tween 80, 15% w/w Span 80, and 65% w/w Captex 300 Low C6. The behavior of SEDDS in pure water and a binary mixture of water and glycerol (58.8% w/w) were investigated by optical microscopy, SAXS (small angle X-ray scattering), dynamic light scattering, and surface tension measurements. The presence of glycerol, at 58.8% w/w, altered the self-emulsification behavior by suppressing the formation of lamellar structures observed in the presence of water, reducing the droplet mean diameter from 0.2 to 0.1 μm and changing the mechanism of self-emulsification. As co-surfactant, glycerol may intercalate within the polyoxyethylene chains of the surfactant at the palisade layer, increasing the interface flexibility and expanding it. Since no free water is available at the investigated glycerol concentration, gly...Continue Reading

References

Dec 1, 1996·Journal of Colloid and Interface Science·B Song, J Springer
May 14, 1999·Pharmaceutical Science & Technology Today·A G Floyd
Mar 23, 2004·Pharmaceutical Research·Robert G Strickley
Apr 15, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R Neslihan Gursoy, Simon Benita
May 4, 2004·Journal of Colloid and Interface Science·Liliana de CampoOtto Glatter
May 18, 2005·Journal of Colloid and Interface Science·Gerardino D'ErricoOrnella Ortona
Jul 11, 2006·The Journal of Physical Chemistry. B·Jennifer L DashnauJane M Vanderkooi
Dec 22, 2007·Drug Development and Industrial Pharmacy·Deepa Patel, Krutika K Sawant
Feb 26, 2008·International Journal of Pharmaceutics·Abhijit A Date, M S Nagarsenker
Aug 24, 2010·Drug Discovery Today·Kanchan KohliRoop K Khar
Nov 3, 2010·The Journal of Pharmacy and Pharmacology·Anette MüllertzThomas Rades
Jul 6, 2014·Journal of Pharmaceutical Sciences·Hywel D WilliamsUNKNOWN Communicated on Behalf of the LFCS Consortium

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Methods Mentioned

BETA
X-ray
dynamic light scattering

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