Self-emulsifying drug delivery system improves preventive effect of curcuminoids on chronic heart failure in rats

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
Yunbin JiangRongping Yang

Abstract

Several studies have reported the preventive or therapeutic effect of curcuminoids on chronic heart failure (CHF), but their application was limited due to low solubility and bioavailability. Our previous study indicates that self-emulsifying drug delivery system (SEDDS) improves the solubility and bioavailability of curcuminoids. Thus, the aim of this work was to investigate whether SEDDS could improve preventive effect of curcuminoids on CHF in rats. CHF model was were established by coronary artery ligation. Ninety rats were randomly and averagely divided into sham, model, low- or high-dose suspension or SEDDS of curcuminoids (66.68 or 266.68 mg/kg) groups. Hemodynamic indices were recorded by multipurpose polygraph. Serum oxidative indices, B-type natriuretic peptide (BNP) and heart weight index were determined by kits and electronic balance. Myocardial infarct area, ventricular dilatation degree and collagen volume fraction of myocardial interstitium were analyzed by Masson staining, picric acid and sirius red staining, light microscopy and image analysis system. Myocardial histopathology was observed by hematoxylin and eosin staining, Masson staining and light microscopy. Reduction of ventricular pump function, increase o...Continue Reading

Citations

Feb 17, 2019·European Journal of Drug Metabolism and Pharmacokinetics·Vinod S IparPadma V Devarajan
Nov 25, 2020·Expert Opinion on Drug Delivery·Vijay MishraAlaa A A Aljabali

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Methods Mentioned

BETA
coronary artery ligation
MDA
light microscopy

Software Mentioned

SPSS
Leica Q500 MC

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