PMID: 6966321May 1, 1980Paper

Self H-2 antigens influence the specificity of alloreactive cells

The Journal of Experimental Medicine
T R Hünig, M J Bevan

Abstract

We have tested Jerne's hypothesis (9) that the phenomenon alloreactivity is explained by the existence of T cells that express germline-encoded receptors specific for major histocompatibility complex antigens and that these cells undergo no change in specificity during thymic differentiation. T cells from [F1 leads to Parent] bone marrow radiation chimeras reactive to conventional antigens are known to have a self preference, i.e., [A X B leads to A] chimeras respond better to H-2A-plus-antigen than to H-2B-plus-antigen. We show here that alloreactive cells from such chimeras also have a self preference. Thus, H-2k-specific alloreactive T cells from [H-2b X H-2d leads to H-2b] and [H-2b X H-2d leads to H-2d] chimeras cross-react more on TNP-modified H-2b or H-2d targets, respectively. In contrast to Jerne's prediction, the results suggest that the receptor repertoire of alloreactive F1 cells is influenced by H-2 antigens on radiation-resistant cells present during T cell ontogeny. By this criterion of having a self preference in H-2 restriction, alloreactive T cells appear to be similar to T cells that respond to conventional antigens.

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M J Bevan
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Nov 1, 1975·The Journal of Experimental Medicine·R D GordonL E Samelson
Aug 1, 1974·European Journal of Immunology·G M Shearer
Jan 1, 1971·European Journal of Immunology·N K Jerne

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Citations

Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M J Bevan, T Hünig
Sep 1, 1980·The Journal of Experimental Medicine·T Hünig, M J Bevan
Jan 1, 1982·The Journal of Experimental Medicine·T R Hünig, M J Bevan
Sep 1, 1982·The Journal of Experimental Medicine·V DuprezS J Burakoff
Mar 22, 2002·Transplantation·Dragana NesićStanislav Vukmanović
Apr 1, 1986·Immunological Reviews·G K SimA A Augustin
Oct 1, 1982·Scandinavian Journal of Immunology·J B Smith, N Talal
Oct 1, 1981·Scandinavian Journal of Immunology·M Hurme, M Sihvola
Mar 1, 1983·Immunology Today·T Hunig

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