Self-healing congenital verruciform hyperkeratosis

American Journal of Medical Genetics. Part a
Christine Léauté-LabrèzeAlain Taïeb

Abstract

We report on an apparently previously undescribed neonatal diffuse congenital hyperkeratosis with spontaneous improvement. The child, born to consanguinous parents, presented at birth with a verrucous hyperkeratosis involving face, trunk, and limbs, but sparing palms and soles. No visceral or skeletal abnormality was associated and neurosensory status was normal. The skin condition improved dramatically during the first month of life. At age 7 years, the child was healthy with normal psychomotor development and growth. He had an abnormal curvature of nose, ulerythema ophryogenes, and large ears. The skin was moderately dry. This favorable clinical outcome led us to propose the term "regressive congenital hyperkeratosis" until further molecular characterization of this new phenotype.

References

Oct 1, 1988·Journal of the American Academy of Dermatology·A FeinsteinM Schewach-Millet
Jan 1, 1988·Archives of Dermatology·H P Baden, B R Bronstein
Feb 1, 1986·Archives of Dermatology·L H BuchbinderA S Paller
Dec 1, 1982·American Journal of Medical Genetics·C J Curry
Dec 1, 1982·American Journal of Medical Genetics·N FitchL Rochon
Aug 18, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·B TaubeA Taïeb
Nov 14, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·A Taïeb, C Labrèze

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Citations

Jan 6, 2009·Journal of the American Academy of Dermatology·Anette BygumFlemming Brandrup

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